ArticleClinical oral investigations2021
Cytocompatibility and bioactive properties of the new dual-curing resin-modified calcium silicate-based material for vital pulp therapy.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 71 citations in OpenAlex.
- Clinical and radiographic outcomes of three calcium silicate-based cements in primary tooth pulpotomy: a randomized clinical trial.BMC oral health · 2026Trial
- Clinical and radiographic outcomes of partial pulpotomy procedure in primary molars utilising different capping materials and different sealing methods: a randomised clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Effects of Nano-Hydroxyapatite-Coated PRF on Gingiva-Derived Mesenchymal Stem Cells: In Vitro Study.International journal of molecular sciences · 2026Article
- Comparison of cytotoxicity and physicochemical properties of Cal Bio LC MTA, ProRoot MTA and NeoPutty MTA: an in vitro study.Odontology · 2026Article
- In Vitro Evaluation of Novel Calcium Silicate-Based and Resin-Modified Calcium Silicate Materials: Cytocompatibility and Mineralization Potential on Human Dental Pulp Stem Cells for Pulp Repair.Microscopy research and technique · 2026Article
- Calcium Silicate-Based Cements for Vital Pulp Therapy: Integrated Assessment of Radiopacity, Elemental Composition, and 24-h Pulp Cell Responses.Biomimetics (Basel, Switzerland) · 2026Article
- Resin-Modified Calcium Silicate-Based Materials Versus Conventional Formulations in Primary Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Outcomes of Vital Pulp Therapy Procedures in Pediatric Dentistry.Journal of functional biomaterials · 2026Review
- In Vitro Evaluation of Novel Resin-Modified Calcium Silicate Cements for Minimally Invasive Vital Pulp Therapy.International dental journal · 2026Article
- Clinical and Radiographic Outcomes of Vital Pulp Therapy Using Resin-Modified Versus Conventional Calcium Silicate-Based Materials: A Systematic Review and Meta-Analysis.Journal of functional biomaterials · 2026Review
- Cytotoxicity, DNA damage, and migration of SHEDs exposed to bioactive pulp capping materials: an in vitro study.BMC oral health · 2026Article
- Diosmin-Capped Silver Nanoparticles Promote Osteogenic Differentiation of Human Periodontal Ligament Stem Cells: Box-Behnken Optimization and in vitro Evaluation.International journal of nanomedicine · 2026Article
- Tailored Ion Release of Polycaprolactone and Calcium Silicate Composite Fibers Attenuates Neutrophil Extracellular Trap Formation for Dentin-Pulp Complex Regeneration.Biomaterials research · 2026Article
- Effect of light-cured pulp capping materials on human dental pulp cells in vitro.International endodontic journal · 2025Article
- Effect of TheraCal PT and Biodentine on inflammatory cell infiltration and hard tissue formation after pulpotomy in inflamed or healthy rat molars.Clinical oral investigations · 2025Article
- Influence of Phase Composition and Morphology on the Calcium Ion Release of Several Classical and Hybrid Endodontic Cements.Materials (Basel, Switzerland) · 2024Article
- Biocompatibility and Cytotoxicity of Pulp-Capping Materials on DPSCs, With Marker mRNA Expressions.International dental journal · 2024Article
- Evaluation of Cytotoxicity of the Dental Materials TheraCal LC, TheraCal PT, ApaCal ART and Biodentine Used in Vital Pulp Therapy: In Vitro Study.Dentistry journal · 2024Article
- Comparative evaluation of dual-cure resin (TheraCal PT) and Biodentine in coronal pulpotomy of patients with symptoms indicative of irreversible pulpitis: A randomized clinical trial.Journal of conservative dentistry and endodontics · 2024Article
- Comparative analysis of cytotoxicity effects of two denture hard lining materials on human gingival fibroblasts: an in vitro study.The Saudi dental journal · 2024Article
- Effect of pulp capping materials on odontogenic differentiation of human dental pulp stem cells: An in vitro study.Clinical and experimental dental research · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThe aim of the present study was to evaluate the in vitro biocompatibility of Theracal PT, Theracal LC, and MTA Angelus, considered as bioactive materials used for vital pulp treatment, on human dental pulp stem cells (hDPSCs). MATERIALS AND
methodsHuman dental pulp stem cells (hDPSCs) were isolated from third molars, and material eluates were prepared (undiluted, 1:2, and 1:4 ratios). The hDPSC cytotoxicity, adhesion, morphology, viability, and cell migration were assessed. The mineralization nodule formation was determined by Alizarin red S staining (ARS). The odonto/osteogenic differentiation potential was assessed by osteo/odontogenic marker expression real-time qPCR. The chemical composition and ion release of the vital pulp materials were determined by energy dispersive X-ray (EDX) and inductively coupled plasma-mass spectrometry (ICP-MS), respectively. Statistical differences were assessed by ANOVA and Tukey's test (p < 0.05).
resultsThe three vital pulp materials showed variable levels of calcium, tungsten, silicon, and zirconium release and in their chemical composition. Cytocompatibility assays revealed higher hDPSC viability and migration rates when treated with Theracal PT than with Theracal LC. The lowest cell adhesion and spreading were observed in all Theracal LC-treated groups, whereas the highest were observed when treated with MTA. Theracal PT and MTA promoted the upregulation of DSPP and RUNX2 gene expression (p < 0.05). After 21 days, both MTA Angelus and Theracal PT-treated cells exhibited a significantly higher mineralized nodule formation than the negative control (p < 0.05).
conclusionsThis study demonstrates the favorable in vitro cytocompatibility and bioactive properties of the recently introduced Theracal PT and the well-established MTA Angelus on hDPSCs, as opposed to Theracal LC. More studies, including in vivo animal testing are suggested before these new formulations might be used in the clinical setting. CLINICAL RELEVANCE: Theracal PT is a new material that could be clinically suitable for vital pulp therapy. Further studies considering its biocompatibility and bioactivity are necessary.
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