Evidence map›Paper›PMID 33638033›Full record

ReviewArchives of dermatological research2022

Unbearable transepidermal water loss (TEWL) experimental variability: why?

Reva P Peer, Anuk Burli, Howard I Maibach

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of dermatological research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Devices measuring transepidermal water loss: A systematic review of measurement properties.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022
    Pooled it
  2. Menopause, Menstrual Cycle, and Skin Barrier Function.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Impact of Air Pollution on Atopic Dermatitis: A Comprehensive Review.Clinical reviews in allergy & immunology · 2023
    Review
  8. Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls.JID innovations : skin science from molecules to population health · 2023
    Article
  9. Review
  10. Review
  11. Delta-5Lipids in health and disease · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Reva P PeerSchool of Medicine and Dentistry, University of Rochester, Rochester, NY, USA. revapeer@gmail.com.
Anuk BurliSchool of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Howard I MaibachDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the wide breadth of research, much disparity exists in transepidermal water loss (TEWL) research data-possibly due to uncontrolled experimental variables. We determined whether such experimental variables significantly impact TEWL studies and cause this disparity. An initial literature search regarding TEWL was performed to determine potential confounding variables. A subsequent search procured relevant and representative studies investigating the impact of these variables on TEWL. Variables, such as age, anatomic site, and temperature, impact TEWL and should be controlled for in TEWL studies. Other variables, such as smoking and menstrual cycle, have inconclusive results or do not provide sufficient data breadth to make a conclusion regarding its effect, if such an effect exists, on TEWL metrics. Therefore, these variables require further research to determine their potential impact on TEWL. Matching for as many experimental variables as possible may reduce the disparity in TEWL data/conclusions.

Indexed as

Water Loss, InsensibleDiagnostic Techniques and ProceduresHumansSkinEvaporimeterExperimental variablesSkinStratum corneumTransepidermal water loss

Identifiers

PMID33638033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.