Evidence map›Paper›PMID 33637886›Full record

ArticleScientific reports2021

Adventitial delivery of nanoparticles encapsulated with 1α, 25-dihydroxyvitamin D

Chuanqi Cai, Sreenivasulu Kilari, Chenglei Zhao, Avishek K Singh, Michael L Simeon, Avanish Misra, Yiqing Li, Edwin Takahashi, Rajiv Kumar, Sanjay Misra

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Nanoparticle-Based Drug Delivery for Vascular Applications.Bioengineering (Basel, Switzerland) · 2024
    Review
  11. Impact of calcitriol and PGDDrug delivery and translational research · 2024
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Bindarit encapsulated nanoparticles prevent venous neointimal hyperplasia and restenosis in a murine angioplasty model.Translational research : the journal of laboratory and clinical medicine · 2022
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chuanqi CaiDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Sreenivasulu KilariVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Chenglei ZhaoVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Avishek K SinghVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Michael L SimeonVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Avanish MisraVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Yiqing LiDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Edwin TakahashiDepartment of Radiology, Vascular and Interventional Radiology, Mayo Clinic, Rochester, MN, USA.
Rajiv KumarDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Sanjay MisraVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. misra.sanjay@mayo.edu.

Funding

The Role of Hypoxia In Venous Neointimal Hyperplasia In Hemodialysis GraftsR01HL098967 · NHLBI · MAYO CLINIC ROCHESTER · PI Sanjay Misra · 2010 to 2026
$10.4M
Fractures and bone disease in living kidney donorsR01DK125252 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV · 2020 to 2022
$2.1M
Regulatory gene-chemokine networks in the formation of hemodialysis AVF stenosisR01DK107870 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV, MISRA, SANJAY · 2017 to 2019
$716k
Regulatory gene-chemokine networks in the formation of hemodialysis AVF stenosisR56DK107870 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV, MISRA, SANJAY · 2020 to 2020
$103k
NHLBI NIH HHS R01 HL098967NIDDK NIH HHS R01 DK107870NIDDK NIH HHS R01 DK125252NIDDK NIH HHS R56 DK107870
6 · The paper itself

Abstract

Percutaneous transluminal angioplasty (PTA) of stenotic arteriovenous fistulas (AVFs) is performed to maintain optimal function and patency. The one-year patency rate is 60% because of venous neointimal hyperplasia (VNH) and venous stenosis (VS) formation. Immediate early response gene X-1 (Iex-1) also known as Ier3 increases in response to wall shear stress (WSS), and can cause VNH/VS formation in murine AVF. In human stenotic samples from AVFs, we demonstrated increased gene expression of Ier3. We hypothesized that 1α, 25-dihydroxyvitamin D

Indexed as

AngioplastyAdultAdventitiaAgedAnimalsApoptosis Regulatory ProteinsArteriovenous FistulaCalcitriolConstriction, PathologicDrug CarriersDrug Delivery SystemsFemaleHumansMaleMembrane ProteinsMiceApoptosis Regulatory ProteinsCalcitriolDrug CarriersIER3 protein, humanMembrane ProteinsVitamins

Identifiers

PMID33637886
PMCPMC7910622

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.