ArticleScientific reports2021
A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Beyond RBD: covert REM sleep abnormalities in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Article
- Rapid eye movement sleep displays distinct fractal dynamics between phasic and tonic states.Neuroscience of consciousness · 2026Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Cortical activity upon awakening from sleep reveals consistent spatio-temporal gradients across sleep stages in human EEG.Current biology : CB · 2025Article
- Temporal progression of sleep electroencephalography features in isolated rapid eye movement sleep behaviour disorder.Journal of sleep research · 2025Article
- Differential motor signatures in isolated and narcolepsy-related REM sleep behaviour disorder: a preliminary study.Frontiers in neurology · 2025Article
- Polysomnographic features associated with clonazepam and melatonin treatment in isolated REM sleep behavior disorder: Time for new therapeutic approaches?CNS neuroscience & therapeutics · 2024Article
- Excessive daytime sleepiness is associated with relative delta frequency power among patients with mild OSA.Frontiers in neurology · 2024Article
- Clinical neurophysiology of REM parasomnias: Diagnostic aspects and insights into pathophysiology.Clinical neurophysiology practice · 2024Review
- Sleep-Related Changes Prior to Cognitive Dysfunction.Current neurology and neuroscience reports · 2023Review
- Comprehensive bibliometric research in neuroscience: focusing on ophthalmology.Frontiers in neuroscience · 2023Article
- Article
- Parasomnias and Disruptive Sleep-Related Disorders: Insights from Local Sleep Findings.Journal of clinical medicine · 2022Article
- Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.Scientific reports · 2022Article
- Restricted truncal sagittal movements of rapid eye movement behaviour disorder.NPJ Parkinson's disease · 2022Article
- Generalized EEG Slowing Across Phasic REM Sleep, Not Subjective RBD Severity, Predicts Neurodegeneration in Idiopathic RBD.Nature and science of sleep · 2022Article
- Capacity for consciousness under ketamine anaesthesia is selectively associated with activity in posteromedial cortex in rats.Neuroscience of consciousness · 2022Article
- Neurophysiological Aspects of REM Sleep Behavior Disorder (RBD): A Narrative Review.Brain sciences · 2021Review
- Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease.Brain : a journal of neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by disrupting motor enactments during REM sleep, but also cognitive impairments across several domains. In addition to REM sleep abnormalities, we hypothesized that RBD patients may also display EEG abnormalities during NREM sleep. We collected all-night recordings with 256-channel high-density EEG in nine RBD patients, predominantly early-onset medicated individuals, nine sex- and age- matched healthy controls, and nine additional controls with matched medications and comorbidities. Power spectra in delta to gamma frequency bands were compared during both REM and NREM sleep, between phasic and tonic REM sleep, and between the first versus last cycle of NREM sleep. Controls, but not RBD patients, displayed a decrease in beta power during phasic compared to tonic REM sleep. Compared to controls, RBD patients displayed a reduced decline in SWA from early to late NREM sleep. Overnight changes in the distribution of the amplitude of slow waves were also reduced in RBD patients. Without suppression of beta rhythms during phasic REM sleep, RBD patients might demonstrate heightened cortical arousal, favoring the emergence of behavioral episodes. A blunted difference between REM sleep sub-stages may constitute a sensitive biomarker for RBD. Moreover, reduced overnight decline in SWA suggests a reduced capacity for synaptic plasticity in RBD patients, which may favor progression towards neurodegenerative diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.