ArticleScientific reports2021
Cerebrospinal fluid (CSF) augments metabolism and virulence expression factors in Acinetobacter baumannii.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- The meninges as a neuroimmune interface: structure, barriers and roles in CNS disease.Fluids and barriers of the CNS · 2026Review
- Clinical characteristics and prognostic factors analysis in patients with post-neurosurgical intracranial infection caused by Acinetobacter baumannii.BMC infectious diseases · 2025Article
- HypervirulentAntibiotics (Basel, Switzerland) · 2025Review
- Transcriptomic and functional profiling ofFrontiers in microbiology · 2025Article
- Human whole blood influences the expression of Acinetobacter baumannii genes related to translation and siderophore production.PloS one · 2025Article
- Cefiderocol in Combating Carbapenem-ResistantBiomedicines · 2024Review
- Whole-genome sequencing of two multidrug-resistant acinetobacter baumannii strains isolated from a neonatal intensive care unit in Egypt: a prospective cross-sectional study.BMC microbiology · 2024Article
- Carbapenem-resistant Acinetobacter baumannii (CRAB): metabolic adaptation and transcriptional response to human urine (HU).Scientific reports · 2024Article
- Carbapenem-resistant Acinetobacter baumannii (CRAB): metabolic adaptation and transcriptional response to human urine (HU).Research square · 2024Article
- Article
- Risk factors and cerebrospinal fluid indexes analysis of intracranial infection by Acinetobacter baumannii after neurosurgery.Heliyon · 2023Article
- Induced Heteroresistance in Carbapenem-ResistantInternational journal of molecular sciences · 2023Article
- The Iron Content of Human Serum Albumin Modulates the Susceptibility ofBiomedicines · 2023Article
- Exposure to Nanoplastic Particles EnhancesNanomaterials (Basel, Switzerland) · 2022Article
- Whole-Genome Sequencing of ST2Antibiotics (Basel, Switzerland) · 2022Article
- Acinetobacter baumannii response to cefiderocol challenge in human urine.Scientific reports · 2022Article
- Human Serum Proteins and Susceptibility ofBiomedicines · 2022Article
- Effect of Serum Albumin, a Component of Human Pleural Fluid, on Transcriptional and Phenotypic Changes on Acinetobacter baumannii A118.Current microbiology · 2021Article
- Interplay between Meropenem and Human Serum Albumin on Expression of Carbapenem Resistance Genes and Natural Competence in Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2021Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 2 countries.
Funding
Abstract
In a recent report by the Centers for Disease Control and Prevention (CDC), multidrug resistant (MDR) Acinetobacter baumannii is a pathogen described as an "urgent threat." Infection with this bacterium manifests as different diseases such as community and nosocomial pneumonia, bloodstream infections, endocarditis, infections of the urinary tract, wound infections, burn infections, skin and soft tissue infections, and meningitis. In particular, nosocomial meningitis, an unwelcome complication of neurosurgery caused by extensively-drug resistant (XDR) A. baumannii, is extremely challenging to manage. Therefore, understanding how A. baumannii adapts to different host environments, such as cerebrospinal fluid (CSF) that may trigger changes in expression of virulence factors that are associated with the successful establishment and progress of this infection is necessary. The present in-vitro work describes, the genetic changes that occur during A. baumannii infiltration into CSF and displays A. baumannii's expansive versatility to persist in a nutrient limited environment while enhancing several virulence factors to survive and persist. While a hypervirulent A. baumannii strain did not show changes in its transcriptome when incubated in the presence of CSF, a low-virulence isolate showed significant differences in gene expression and phenotypic traits. Exposure to 4% CSF caused increased expression of virulence factors such as fimbriae, pilins, and iron chelators, and other virulence determinants that was confirmed in various model systems. Furthermore, although CSF's presence did not enhance bacterial growth, an increase of expression of genes encoding transcription, translation, and the ATP synthesis machinery was observed. This work also explores A. baumannii's response to an essential component, human serum albumin (HSA), within CSF to trigger the differential expression of genes associated with its pathoadaptibility in this environment.
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