ArticleScientific reports2021
Genome-wide identification and functional characterization of natural antisense transcripts in Salvia miltiorrhiza.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 27 citations in OpenAlex.
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- Genome-Wide Identification and Characterization of miRNAs and Natural Antisense Transcripts Show the Complexity of Gene Regulatory Networks for Secondary Metabolism inInternational journal of molecular sciences · 2024Article
- Global identification of natural antisense transcripts iniScience · 2023Article
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- Comprehensive Analysis of Carotenoid Cleavage Dioxygenases Gene Family and Its Expression in Response to Abiotic Stress in Poplar.International journal of molecular sciences · 2022Article
- Genome-Wide Characterization and Expression Analysis of Pathogenesis-Related 1 (International journal of molecular sciences · 2022Article
- Genome-wide identification of antisense lncRNAs and their association with susceptibility toFrontiers in immunology · 2022Article
- Genome-wide identification and multiple abiotic stress transcript profiling of potassium transport gene homologs inFrontiers in plant science · 2022Article
- Transcriptome Analysis Reveals Candidate Genes Involved in Light-Induced Primordium Differentiation inInternational journal of molecular sciences · 2021Article
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- Genome-Wide Identification, Genomic Organization, and Characterization of Potassium Transport-Related Genes inPlants (Basel, Switzerland) · 2021Article
- Genome-Wide Analysis and the Expression Pattern of the MADS-Box Gene Family inPlants (Basel, Switzerland) · 2021Article
- Genomic-Wide Identification and Characterization of the Uridine Diphosphate Glycosyltransferase Family inPlants (Basel, Switzerland) · 2021Article
- Novel insights on the positive correlation between sense and antisense pairs on gene expression.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salvia miltiorrhiza is one of the most widely used traditional medicines. Natural antisense transcripts (NATs) are a class of long noncoding RNAs that can regulate gene expression. Here, we identified 812 NATs, including 168 cis-NATs and 644 trans-NATs from twelve root, flower, and leaf samples of S. miltiorrhiza using RNA-seq. The expression profiles for 41 of 50 NATs and their sense transcripts (STs) obtained from RNA-Seq were validated using qRT-PCR. The expression profiles of 17 NATs positively correlated with their STs. GO and KEGG pathway analyses mapped the STs for cis-NATs to pathways for biosynthesis of secondary metabolites. We characterized four NATs in detail, including NAT0001, NAT0002, NAT0004, and NAT00023. Their STs are kaurene synthase-like 1 and the homologs of UDP-glucose flavonoid 3-O-glucosyltransferase 6, UDP-glycosyltransferase 90A1, and beta-glucosidase 40, respectively. The first gene is involved in the biosynthesis of bioactive tanshinones, the next two are involved in anthocyanin biosynthesis, whereas the last is involved in phenylpropanoid biosynthesis. Besides, we found seven STs that are potential targets of miRNAs. And we found two miRNAs including miR156a and miR7208, might originate from NATs, NAT0112 and NAT0086. The results suggest that S. miltiorrhiza NATs might interact with STs, produce miRNAs, and be regulated by miRNAs. They potentially play significant regulatory roles in the biosynthesis of bioactive compounds.
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