Evidence map›Paper›PMID 33637789›Full record

ArticleScientific reports2021

Toll-like receptor-9 stimulated plasmacytoid dendritic cell precursors suppress autoimmune neuroinflammation in a murine model of multiple sclerosis.

Hélène Letscher, Viviane A Agbogan, Sarantis Korniotis, Pauline Gastineau, Emmanuel Tejerina, Christophe Gras, Jérôme Mégret, Alison Moe, William R Drobyski, Flora Zavala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Hélène Letscher *Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Université de Paris, 156 rue de Vaugirard, 75015, Paris, France.
Viviane A Agbogan *Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Université de Paris, 156 rue de Vaugirard, 75015, Paris, France.
Sarantis KorniotisInstitut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Université de Paris, 156 rue de Vaugirard, 75015, Paris, France.
Pauline GastineauInstitut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Université de Paris, 156 rue de Vaugirard, 75015, Paris, France.
Emmanuel TejerinaInstitut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Université de Paris, 156 rue de Vaugirard, 75015, Paris, France.
Christophe GrasInstitut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Université de Paris, 156 rue de Vaugirard, 75015, Paris, France.
Jérôme MégretStructure Fédérative de Recherche Necker, INSERM US24, CNRS UMS 3633, 75015, Paris, France.
Alison MoeDepartment of Medicine, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI, 53226, USA.
William R DrobyskiDepartment of Medicine, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI, 53226, USA.
Flora ZavalaInstitut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Université de Paris, 156 rue de Vaugirard, 75015, Paris, France. flora.zavala@inserm.fr.
Université Paris Cité · FRInserm · FRInstitut Necker Enfants Malades · FRMedical College of Wisconsin · USStructure fédérative de recherche Necker

Funding

Role of Interleukin 23 in Gastrointestinal GVHDR01HL126166 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI William R. Drobyski · 2015 to 2026
$5.4M
Cannabinoid-mediated mitigation of graft versus host disease: Roles of CB2 receptors and adenosine signalingR01HL139008 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI DROBYSKI, WILLIAM R., HILLARD, CECILIA J · 2017 to 2020
$2.2M
NHLBI NIH HHS R01 HL126166NHLBI NIH HHS R01 HL139008
6 · The paper itself

Abstract

Early innate education of hematopoietic progenitors within the bone marrow (BM) stably primes them for either trained immunity or instead immunoregulatory functions. We herein demonstrate that in vivo or in vitro activation within the BM via Toll-like receptor-9 generates a population of plasmacytoid dendritic cell (pDC) precursors (CpG-pre-pDCs) that, unlike pDC precursors isolated from PBS-incubated BM (PBS-pre-pDCs), are endowed with the capacity to halt progression of ongoing experimental autoimmune encephalomyelitis. CpG activation enhances the selective migration of pDC precursors to the inflamed spinal cord, induces their immediate production of TGF-β, and after migration, of enhanced levels of IL-27. CpG-pre-pDC derived TGF-β and IL-27 ensure protection at early and late phases of the disease, respectively. Spinal cords of CpG-pre-pDC-protected recipient mice display enhanced percentages of host-derived pDCs expressing TGF-β as well as an accumulation of IL-10 producing B cells and of CD11c

Indexed as

AnimalsBone Marrow CellsDendritic CellsDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleInterleukin-27MiceMice, Inbred C57BLMice, KnockoutMultiple SclerosisSpinal CordToll-Like Receptor 9Transforming Growth Factor betaInterleukin-27Toll-Like Receptor 9Transforming Growth Factor beta

Identifiers

PMID33637789
PMCPMC7910458
OpenAlexW3131864335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.