Evidence map›Paper›PMID 33637777›Full record

ArticleScientific reports2021

Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice.

Heather Mahoney, Emily Peterson, Hannah Justin, David Gonzalez, Christopher Cardona, Korey Stevanovic, John Faulkner, Amara Yunus, Alexandra Portugues, Amy Henriksen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Heather MahoneyByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Emily PetersonByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Hannah JustinByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
David GonzalezByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Christopher CardonaByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Korey StevanovicNational Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC, USA.
John FaulknerByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Amara YunusCollege of Pharmacy, University of Florida, Gainesville, FL, USA.
Alexandra PortuguesByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Amy HenriksenByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Camden BurnsByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Cameron McNeillUSF Health Informatics Institute, University of South Florida Health, Tampa, FL, USA.
Joshua GamsbyByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA.
Danielle GulickByrd Alzheimer's Institute, University of South Florida Health, Tampa, FL, USA. dgulick@usf.edu.
University of South Florida · USUSF Health Byrd Alzheimer's Institute · USNational Institute of Environmental Health Sciences · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of the circadian system, either at the level of the master clock in the SCN or downstream, impairs hippocampus-dependent learning and memory. A number of kinases, including the serine-threonine casein kinase 1 (CK1) isoforms CK1δ/ε, regulate the timing of the circadian period through post-translational modification of clock proteins. Modulation of these circadian kinases presents a novel treatment direction for cognitive deficits through circadian modulation. Here, we tested the potential for PF-670462, a small molecule inhibitor of CK1δ/ε, to improve cognitive performance in C57BL/6J mice in an array of behavioral tests. Compared to vehicle-treated mice tested at the same time of the circadian day, mice treated with PF-670462 displayed better recall of contextual fear conditioning, made fewer working memory errors in the radial arm water maze, and trained more efficiently in the Morris Water Maze. These benefits were accompanied by increased expression of activity-regulated cytoskeleton-associated protein (Arc) in the amygdala in response to an acute learning paradigm. Our results suggest the potential utility of CK1δ/ε inhibition in improving time-of-day cognitive performance.

Indexed as

CognitionAmygdalaAnimalsCasein Kinase 1 epsilonCasein Kinase IdeltaCLOCK ProteinsConditioning, PsychologicalCytoskeletal ProteinsLearningMaze LearningMemoryMiceMice, Inbred C57BLNerve Tissue ProteinsPyrimidinesactivity regulated cytoskeletal-associated proteinCasein Kinase 1 epsilonCasein Kinase IdeltaCLOCK ProteinsCytoskeletal ProteinsNerve Tissue ProteinsPF-670462Pyrimidines

Identifiers

PMID33637777
PMCPMC7910436
OpenAlexW3132714607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.