ArticleScientific reports2021
Investigation of biological activity of soil fungal extracts and LC/MS-QTOF based metabolite profiling.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Anti-staphylococcal activity of soil-derived Penicillium citrinum extract.BMC microbiology · 2026Article
- Bioprospecting Heavy-Metal Rhizospheres for Novel Therapeutics Against High-Priority Multi-Drug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii: A Case of Toxic to Treatment.Environmental microbiology reports · 2025Article
- Bioactive Compounds From Saudi Arabian Fungi: A Systematic Review of Anticancer Potential.Clinical pharmacology : advances and applications · 2025Review
- Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungiFrontiers in fungal biology · 2025Article
- Metabolic profiling, antimicrobial, anticancer, and in vitro and in silico immunomodulatory investigation of Aspergillus niger OR730979 isolated from the Western Desert, Egypt.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- The effect of natural herbicide from Fusarium equiseti crude extract on the aquatic weed water hyacinth (Eichornia crassipes (Mart.) Solms).Scientific reports · 2024Article
- Microbial diversity in polyextreme salt flats and their potential applications.Environmental science and pollution research international · 2024Review
- Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis.Communications biology · 2024Article
- Article
- Anti-Staphylococcal, Anti-Candida, and Free-Radical Scavenging Potential of Soil Fungal Metabolites: A Study Supported by Phenolic Characterization and Molecular Docking Analysis.Current issues in molecular biology · 2023Article
- Antimicrobial Potential of Different Isolates ofBiomolecules · 2023Article
- Fungi associated with ornamental plants in some Nurseries in Al-Qurayyat, Jouf region, Saudi Arabia.Iranian journal of microbiology · 2023Article
- Article
- In Vitro Efficacy of Extracts and Isolated Bioactive Compounds from Ascomycota Fungi in the Treatment of Colorectal Cancer: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Antimicrobial Activity ofInternational journal of microbiology · 2022Article
- Silver Nanoparticles Formation byNanomaterials (Basel, Switzerland) · 2021Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soil is considered an extensively explored ecological niche for microorganisms that produce useful biologically active natural products suitable for pharmaceutical applications. The current study aimed at investigating biological activities and metabolic profiles of three fungal strains identified from different desert sites in Saudi Arabia. Soil fungal isolates were collected from AlQasab, Tabuk, and Almuzahimiyah in Saudi Arabia and identified. Furthermore, their antibacterial activity was investigated against Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumonia, and Escherichia coli in blood, nutrient, and Sabouraud dextrose agars. Moreover, fungal extracts were evaluated on cell viability/proliferation against human breast carcinoma and colorectal adenocarcinoma cells. To identify the biomolecules of the fungal extracts, High-performance liquid chromatography HPLC-DAD coupled to analytical LC-QTOF-MS method was employed for fungal ethyl acetate crude extract. Identified fungal isolates, Chaetomium sp. Bipolaris sp. and Fusarium venenatum showed varied inhibitory activity against tested microbes in relation to crude extract, microbial strain tested, and growth media. F. venenatum showed higher anticancer activity compared to Chaetomium sp. and Bipolaris sp. extracts against four of the tested cancer cell lines. Screening by HPLC and LC/MS-QTOF identified nine compounds from Chaetomium sp. and three from Bipolaris sp. however, for F. venenatum extracts compounds were not fully identified. In light of the present findings, some biological activities of fungal extracts were approved in vitro, suggesting that such extracts could be a useful starting point to find compounds that possess promising agents for medical applications. Further investigations to identify exact biomolecules from F. venenatum extracts are needed.
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