Evidence map›Paper›PMID 33637766›Full record

ArticleNature communications2021

Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis.

Ji-Yun Seo, Jong-Seol Kang, Ye Lynne Kim, Young-Woo Jo, Ji-Hoon Kim, Sang-Hyeon Hann, Jieon Park, Inkuk Park, Hyerim Park, Kyusang Yoo and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Function and Molecular Mechanism of Circhomer1 in Myogenesis.International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Epigenetics of Skeletal Muscle Atrophy.International journal of molecular sciences · 2024
    Review
  9. Reciprocal communication between FAPs and muscle cells via distinct extracellular vesicle miRNAs in muscle regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Ubiquitin Ligases in Longevity and Aging Skeletal Muscle.International journal of molecular sciences · 2022
    Review
  12. Current Thoughts of Notch's Role in Myoblast Regulation and Muscle-Associated Disease.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ji-Yun SeoSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0003-0145-6344
Jong-Seol KangSchool of Biological Sciences, Seoul National University, Seoul, South Korea.
Ye Lynne KimSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-2514-9835
Young-Woo JoSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-4230-8682
Ji-Hoon KimSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-9217-4483
Sang-Hyeon HannSchool of Biological Sciences, Seoul National University, Seoul, South Korea.
Jieon ParkSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-4407-1797
Inkuk ParkSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0001-8261-4433
Hyerim ParkSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-1607-5205
Kyusang YooSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-9852-5344
Joonwoo RheeSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-2790-7935
Jung-Wee ParkDepartment of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0002-4515-1895
Yong Chan HaDepartment of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, South Korea.
Young-Yun KongSchool of Biological Sciences, Seoul National University, Seoul, South Korea. ykong@snu.ac.kr.ORCID http://orcid.org/0000-0001-7335-3729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-associated muscle atrophy is a debilitating condition associated with loss of muscle mass and function with age that contributes to limitation of mobility and locomotion. However, the underlying mechanisms of how intrinsic muscle changes with age are largely unknown. Here we report that, with age, Mind bomb-1 (Mib1) plays important role in skeletal muscle maintenance via proteasomal degradation-dependent regulation of α-actinin 3 (Actn3). The disruption of Mib1 in myofibers (Mib1

Indexed as

ActininAgingAnimalsGene Expression RegulationGenotypeHEK293 CellsHumansMaleMiceMice, Inbred C57BLMuscle, SkeletalProteasome Endopeptidase ComplexTranscriptomeUbiquitin-Protein LigasesActininACTN3 protein, humanActn3 protein, mouseMIB1 protein, mouseProteasome Endopeptidase ComplexUbiquitin-Protein Ligases

Identifiers

PMID33637766
PMCPMC7910585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.