ArticleNeurology2021
Association of White Matter Hyperintensities With HIV Status and Vascular Risk Factors.
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Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Impact of cannabis use on white matter hyperintensities in adults with and without chronic HIV disease.Journal of neurovirology · 2026Article
- Portable Low-Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus.Annals of clinical and translational neurology · 2026Article
- Article
- Risk Factors Associated With Incident Dementia in People Living With HIV.Journal of Korean medical science · 2025Observational
- Cerebrospinal fluid biomarkers of inflammation and immune activation associated with neurocognitive impairment among US Latinos with HIV.AIDS (London, England) · 2025Article
- Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV.Neurology · 2025Article
- HIV-Tat and vascular endothelium: implications in the HIV associated brain, heart, and lung complications.Frontiers in immunology · 2025Review
- Contributions of Cerebral White Matter Hyperintensities to Postural Instability in Aging With and Without Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- White and Gray Matter Changes are Associated With Neurocognitive Decline in HIV Infection.Annals of neurology · 2024Article
- Mechanisms of HIV-mediated blood-brain barrier compromise and leukocyte transmigration under the current antiretroviral era.iScience · 2024Article
- Age-Accelerated Increase of White Matter Hyperintensity Volumes Is Exacerbated by Heavy Alcohol Use in People Living With HIV.Biological psychiatry · 2024Article
- Elevated Plasma Protein Carbonyl Concentration Is Associated with More Abnormal White Matter in People with HIV.Viruses · 2023Article
- Cocaine use is associated with cerebral white matter hyperintensities in HIV disease.Annals of clinical and translational neurology · 2023Article
- Elevated frequency and everyday functioning implications of vascular depression in persons with HIV disease.Journal of psychiatric research · 2023Article
- Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging.The Journal of infectious diseases · 2023Article
- Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI.Brain : a journal of neurology · 2023Article
- Influence of HIV infection on cognition and overall intelligence in HIV-infected individuals: advances and perspectives.Frontiers in behavioral neuroscience · 2023Review
- Pseudo-Label Assisted nnU-Net enables automatic segmentation of 7T MRI from a single acquisition.Frontiers in neuroimaging · 2023Article
- Low levels of peripheral blood activated and senescent T cells characterize people with HIV-1-associated neurocognitive disorders.Frontiers in immunology · 2023Article
- Initiation of combined antiretroviral therapy confers suboptimal beneficial effects on neurovascular function in people with HIV.Frontiers in neurology · 2023Article
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Authors and funding
17 authors at 1 institution in 2 countries.
Yair MinaFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.ORCID http://orcid.org/0000-0003-2311-6623
Tianxia WuFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Hsing-Chuan HsiehFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Dima A HammoudFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Swati ShahFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Chuen-Yen LauFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Lillian HamFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Joseph SnowFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.ORCID http://orcid.org/0000-0002-3015-1171
Elizabeth HorneFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Anuradha GanesanFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Stanley I RapoportFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Edmund C TramontFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Daniel S ReichFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.ORCID http://orcid.org/0000-0002-2628-4334
Brian K AganFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.
Avindra NathFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD.ORCID http://orcid.org/0000-0003-0927-5855
Bryan R SmithFrom the National Institute of Neurological Disorders and Stroke (Y.M., T.W., E.H., D.S.R., A.N., B.R.S.), Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center (D.A.H., S.S.), National Institute of Allergy and Infectious Diseases (C.-Y.L., E.C.T.), National Institute of Mental Health (L.H., J.S.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), National Institutes of Health, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics (H.-C.H., A.G., B.K.A.), Uniformed Services University of the Health Sciences; and Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (H.-C.H., A.G., B.K.A.), Bethesda, MD. bryan.smith2@nih.gov.
NIH-DOD NeuroHIV Consortium
Henry M. Jackson Foundation · US
Funding
Neuropathogenesis of Retroviral InfectionsZIANS003130 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2011 to 2025
$73.7MMultimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4MPsychiatry Consultation Liaison Service ResearchZIAMH002922 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PAO, MARYLAND · 2009 to 2025
$11.5MAbstract
objectiveTo test the hypothesis that brain white matter hyperintensities (WMH) are more common in people living with HIV (PLWH), even in the setting of well-controlled infection, and to identify clinical measures that correlate with these abnormalities.
methodsResearch brain MRI scans, acquired within longitudinal studies evaluating neurocognitive outcomes, were reviewed to determine WMH load using the Fazekas visual rating scale in PLWH with well-controlled infection (antiretroviral therapy for at least 1 year and plasma viral load <200 copies/mL) and in sociodemographically matched controls without HIV (CWOH). The primary outcome measure of this cross-sectional analysis was increased WMH load, determined by total Fazekas score ≥2. Multiple logistic regression analysis was performed to evaluate the effect of HIV serostatus on WMH load and to identify MRI, CSF, and clinical variables that associate with WMH in the PLWH group.
resultsThe study included 203 PLWH and 58 CWOH who completed a brain MRI scan between April 2014 and March 2019. The multiple logistic regression analysis, with age and history of tobacco use as covariates, showed that the adjusted odds ratio of the PLWH group for increased WMH load is 3.7 (95% confidence interval 1.8-7.5;
conclusionOur results suggest that HIV serostatus affects the extent of brain WMH. This effect is mainly associated with aging and modifiable comorbidities.
Indexed as
AdultBrainCross-Sectional StudiesFemaleHIV InfectionsHumansLeukoaraiosisLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsWhite Matter
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