Evidence map›Paper›PMID 33637602›Full record

ReviewJournal for immunotherapy of cancer2021

CXCL9-expressing tumor-associated macrophages: new players in the fight against cancer.

Paola Marie Marcovecchio, Graham Thomas, Shahram Salek-Ardakani

Open access · goldAbstract readReview
In one paragraph

Review in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 119 citations in OpenAlex.

  1. Trial
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  5. HIV Transmission and Immunology of the Male Reproductive Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  6. CD8Reproductive sciences (Thousand Oaks, Calif.) · 2026
    Article
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Paola Marie MarcovecchioCancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
Graham ThomasCancer Immunology Discovery, Pfizer Inc, San Diego, California, USA.
Shahram Salek-ArdakaniCancer Immunology Discovery, Pfizer Inc, San Diego, California, USA shahram.salek-ardakani@pfizer.com.ORCID 0000-0002-2336-8452
Pfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) are among the main contributors to immune suppression in the tumor microenvironment, however, TAM depletion strategies have yielded little clinical benefit. Here, we discuss the concept that TAMs are also key regulators of anti-PD(L)-1-mediated CD8 T cell-dependent immunity. Emerging data suggest that expression of the chemokine CXCL9 by TAMs regulates the recruitment and positioning of CXCR3-expressing stem-like CD8 T (T

Indexed as

Tumor EscapeAnimalsB7-H1 AntigenCD8-Positive T-LymphocytesChemokine CXCL9HumansImmune Checkpoint InhibitorsImmunotherapyLymphocytes, Tumor-InfiltratingNeoplasmsReceptors, CXCR3Signal TransductionTumor-Associated MacrophagesTumor MicroenvironmentB7-H1 AntigenCD274 protein, humanChemokine CXCL9CXCL9 protein, humanCXCR3 protein, humanImmune Checkpoint InhibitorsReceptors, CXCR3CD8-Positive T-Lymphocytesimmunotherapymacrophagesreview

Identifiers

PMID33637602
PMCPMC7919587
OpenAlexW3133035964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.