Observational studyScience immunology2021
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation.
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 171 citations in OpenAlex.
- Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma.Nature communications · 2025Trial
- Persistent COVID-19 parosmia and olfactory loss post olfactory training: randomized clinical trial comparing central and peripheral-acting therapeutics.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Trial
- Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026Review
- Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade.eLife · 2026Article
- CD25 expression marks an activated mast cell population in human nasal polyposis.The Journal of allergy and clinical immunology · 2026Article
- Mast Cells in the Developing Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches.Pharmacological reviews · 2026Review
- Multi-Omics Analysis Reveals Abnormal Metabolism of Lysophosphatidylinositol in Nasal Polyp.Allergy, asthma & immunology research · 2026Article
- Single-Cell Omics Analysis of Human Basophils Reveals Two Transcriptionally Distinct Populations.Allergy · 2026Article
- Inflammatory memory: the core mechanism driving allergic asthma recurrence and chronicity.Journal of thoracic disease · 2026Review
- Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N-ERD Patients.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Spatial atlas of gastric cancer reveals macrophage-driven stromal activation via ICAM1⁺ smooth muscle cells.BMC cancer · 2026Article
- Emerging Systemic Treatments for Asthma and Allergic Diseases: New Tricks, Same Dog?The journal of allergy and clinical immunology. In practice · 2026Review
- Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024).World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Single-cell transcriptomics of granulocytes in asthma and atopic diseases.Frontiers in molecular biosciences · 2026Review
- Progress in cellular mechanisms of chronic rhinosinusitis.Fundamental research · 2026Review
- Review
- Article
- Platelets engage mast cells in a bilateral IL-33-driven feed-forward loop.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to ingested antigens.Science (New York, N.Y.) · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 3 countries.
Daniel F DwyerJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-5029-261X
Jose Ordovas-MontanesDivision of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-5444-5601
Samuel J AllonBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-8381-3159
Kathleen M BuchheitJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Marko VukovicBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Tahereh DerakhshanJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-8829-4415
Chunli FengJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-5048-9073
Juying LaiJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Travis K HughesBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sarah K NyquistBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Matthew P GiannettiJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-3655-1835
Bonnie BergerComputer Science and Artificial Intelligence Lab and Department of Mathematics, MIT, Cambridge, MA, USA.ORCID 0000-0002-2724-7228
Neil BhattacharyyaDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0000-5824
Rachel E RoditiDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7899-6336
Howard R KatzJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.
Martijn C NawijnGroningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID 0000-0003-3372-6521
Marijn BergGroningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Maarten van den BergeGroningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Tanya M LaidlawJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-6709-9795
Alex K ShalekBroad Institute of MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu jboyce@rics.bwh.harvard.edu nbarrett@bwh.harvard.edu.ORCID 0000-0001-5670-8778
Nora A BarrettJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA. shalek@mit.edu jboyce@rics.bwh.harvard.edu nbarrett@bwh.harvard.edu.ORCID 0000-0003-2211-8811
Joshua A BoyceJeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA. shalek@mit.edu jboyce@rics.bwh.harvard.edu nbarrett@bwh.harvard.edu.ORCID 0000-0002-2401-2351
Brigham and Women's Hospital · USBroad Institute · USUniversity Medical Center Groningen · NLArtificial Intelligence in Medicine (Canada) · CA
Funding
TRM and airway inflammation and remodelingU19AI070535 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2006 to 2025
$34.2MSTRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI LYNN BRY · 1986 to 2026
$32.4MTherapeutic Control of Aspirin-Exacerbated Respiratory DiseaseU19AI095219 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Maria Gutierrez-Arcelus · 2011 to 2026
$29.1MIMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYT32AI007306 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett, Joshua A Boyce · 1985 to 2026
$12.2MRegulation of Pulmonary Prostaglandins by Leukotriene E4R01AI078908 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BOYCE, JOSHUA A · 2009 to 2025
$8.8MEicosanoid Networks in Aspirin HypersensitivityR01AI136041 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Joshua A Boyce · 2018 to 2026
$5.4MCysLT and P2Y Receptors in Lung InflammationR37AI052353 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BOYCE, JOSHUA A · 2013 to 2022
$5.2MType 2 Inflammation and Remodeling Elicited Through an LTE4/OXGR1-dependent pathwayR01AI134989 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett · 2019 to 2026
$5.1MGraduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6MProstaglandin D2: A Key Mediator of Aspirin-Exacerbated Respiratory DiseaseR01HL128241 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LAIDLAW, TANYA MARIA · 2015 to 2019
$2.2MOptimizing EP receptor subtype targeting for asthma therapyR01HL136209 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI BIRRELL, MARK A, BOYCE, JOSHUA A · 2017 to 2020
$2.2MAn integrated multiplexed genomic assay for low input clinical samples1U24AI118672 · NIAID · BROAD INSTITUTE, INC. · PI SHALEK, ALEX K · 2015 to 2019
$2.0MHoward Hughes Medical InstituteNHLBI NIH HHS R01 HL120952NHLBI NIH HHS R01 HL128241NHLBI NIH HHS R01 HL136209NIAID NIH HHS K22 AI146281NIAID NIH HHS K23 AI139352NIAID NIH HHS R01 AI078908NIAID NIH HHS R01 AI134989NIAID NIH HHS R01 AI136041NIAID NIH HHS R37 AI052353NIAID NIH HHS T32 AI007306NIAID NIH HHS U19 AI070535NIAID NIH HHS U19 AI095219NIAID NIH HHS U24 AI118672NIDDK NIH HHS P30 DK034854NIGMS NIH HHS T32 GM087237
Abstract
Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). Distinct MC subsets infiltrate the airway mucosa in T2 disease, including subepithelial MCs expressing the proteases tryptase and chymase (MC
Indexed as
AdultAgedCell ProliferationEndoscopyFemaleFlow CytometryHumansMaleMast CellsMiddle AgedNasal MucosaNasal PolypsNasal Surgical ProceduresRhinitisRNA-SeqSingle-Cell Analysis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.