Evidence map›Paper›PMID 33637560›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear.

Abha K Rajbhandari, Christopher J Octeau, Sarah Gonzalez, Zachary T Pennington, Farzanna Mohamed, Jeremy Trott, Jasmine Chavez, Erin Ngyuen, Natasha Keces, Weizhe Z Hong and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. PACAP regulates neuroendocrine and behavioral stress responses via CRF-containing neurons of the rat hypothalamic paraventricular nucleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Neural Circuit Transitions Supporting Developmentally Specific Social Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Abha K RajbhandariDepartment of Psychology, University of California, Los Angeles, California 90095 abha.rajbhandari@mssm.edu.
Christopher J OcteauDepartment of Physiology, University of California, Los Angeles, California 90095.
Sarah GonzalezDepartment of Psychology, University of California, Los Angeles, California 90095.
Zachary T PenningtonDepartment of Psychology, University of California, Los Angeles, California 90095.
Farzanna MohamedDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Jeremy TrottDepartment of Psychology, University of California, Los Angeles, California 90095.
Jasmine ChavezDepartment of Psychology, University of California, Los Angeles, California 90095.
Erin NgyuenDepartment of Psychology, University of California, Los Angeles, California 90095.
Natasha KecesDepartment of Psychology, University of California, Los Angeles, California 90095.
Weizhe Z HongDepartment of Neurobiology, University of California, Los Angeles, California 90095.
Rachael L NeveGene Delivery Technology Core, Massachusetts General Hospital, Boston, Massachusetts, California 02114.
James WaschekDepartment of Psychiatry, University of California, Los Angeles, California 90095.
Baljit S KhakhDepartment of Physiology, University of California, Los Angeles, California 90095.
Michael S FanselowDepartment of Psychology, University of California, Los Angeles, California 90095.
University of California, Los Angeles · USIcahn School of Medicine at Mount Sinai · USMassachusetts General Hospital · US

Funding

Contextual Fear Differentiation, Sex Differences and AcetylcholineR01MH062122 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S · 2001 to 2021
$7.3M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress DisorderR21MH098506 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S, WASCHEK, JAMES A · 2013 to 2014
$424k
Dissecting the role of the amygdala intercalated cells in expression, generalization and extinction of stress-enhanced fear learningF32MH107212 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAJBHANDARI, ABHA K · 2015 to 2017
$112k
NIDA NIH HHS T32 DA024635NIMH NIH HHS F32 MH107212NIMH NIH HHS R01 MH062122NIMH NIH HHS R21 MH098506
6 · The paper itself

Abstract

Trauma can cause dysfunctional fear regulation leading some people to develop disorders, such as post-traumatic stress disorder (PTSD). The amygdala regulates fear, whereas PACAP (pituitary adenylate activating peptide) and PAC1 receptors are linked to PTSD symptom severity at genetic/epigenetic levels, with a strong link in females with PTSD. We discovered a PACAPergic projection from the basomedial amygdala (BMA) to the medial intercalated cells (mICCs) in adult mice.

Indexed as

FearAmygdalaAnimalsExcitatory Postsynaptic PotentialsExtinction, PsychologicalFemaleMaleMiceMice, Inbred C57BLNeuronsOptogeneticsPituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type ISex FactorsStress Disorders, Post-TraumaticAdcyap1 protein, mouseAdcyap1r1 protein, mousePituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IamygdalafearPACAP

Identifiers

PMID33637560
PMCPMC8051692
OpenAlexW3131426423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.