Evidence map›Paper›PMID 33637538›Full record

ArticleeNeuro

A Role for STOML3 in Olfactory Sensory Transduction.

Emilio Agostinelli, Kevin Y Gonzalez-Velandia, Andres Hernandez-Clavijo, Devendra Kumar Maurya, Elena Xerxa, Gary R Lewin, Michele Dibattista, Anna Menini, Simone Pifferi

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Emilio AgostinelliNeurobiology Group, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste 34136, Italy.
Kevin Y Gonzalez-VelandiaNeurobiology Group, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste 34136, Italy.
Andres Hernandez-ClavijoNeurobiology Group, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste 34136, Italy.ORCID 0000-0002-4122-3521
Devendra Kumar MauryaNeurobiology Group, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste 34136, Italy.
Elena XerxaNeurobiology Group, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste 34136, Italy.
Gary R LewinMolecular Physiology of Somatic Sensation, Department of Neuroscience, Max Delbrück Center for Molecular Medicine, Berlin D-13122, Germany.ORCID 0000-0002-2890-6352
Michele DibattistaDepartment of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari A. Moro, Bari 70124, Italy spifferi@sissa.it menini@sissa.it michele.dibattista@uniba.it.
Anna MeniniNeurobiology Group, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste 34136, Italy spifferi@sissa.it menini@sissa.it michele.dibattista@uniba.it.ORCID 0000-0001-9304-0412
Simone PifferiNeurobiology Group, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste 34136, Italy spifferi@sissa.it menini@sissa.it michele.dibattista@uniba.it.ORCID 0000-0002-3687-3984
Scuola Internazionale Superiore di Studi Avanzati · ITMarche Polytechnic University · ITMax Delbrück Center · DEUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stomatin-like protein-3 (STOML3) is an integral membrane protein expressed in the cilia of olfactory sensory neurons (OSNs), but its functional role in this cell type has never been addressed. STOML3 is also expressed in dorsal root ganglia neurons, where it has been shown to be required for normal touch sensation. Here, we extended previous results indicating that STOML3 is mainly expressed in the knob and proximal cilia of OSNs. We additionally showed that mice lacking STOML3 have a morphologically normal olfactory epithelium. Because of its presence in the cilia, together with known olfactory transduction components, we hypothesized that STOML3 could be involved in modulating odorant responses in OSNs. To investigate the functional role of STOML3, we performed loose patch recordings from wild-type (WT) and

Indexed as

Olfactory Receptor NeuronsSmellAnimalsCiliaMembrane ProteinsMiceNerve Tissue ProteinsOlfactory MucosaMembrane ProteinsNerve Tissue ProteinsStoml3 protein, mouseion channelolfactorytransduction

Identifiers

PMID33637538
PMCPMC7986538
OpenAlexW3132208766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.