Evidence map›Paper›PMID 33637535›Full record

ArticleScience advances2021

A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light.

Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Jagan Mohan Obbineni, Noemi Zimmermann, Masako Nakajima and 22 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. mSphere · 2024
    Article
  2. Article
  3. Article
  4. Structure of Motile Cilia.Sub-cellular biochemistry · 2022
    Article
  5. Towards the Idea of Molecular Brains.International journal of molecular sciences · 2021
    Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 8 institutions in 3 countries.

Osamu KutomiShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.ORCID 0000-0003-2899-365X
Ryosuke YamamotoShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.ORCID 0000-0002-5282-2343
Keiko HiroseBiomedical Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.
Katsutoshi MizunoShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.ORCID 0000-0002-9584-3953
Yuuhei NakagiriDepartment of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.ORCID 0000-0001-9688-2789
Hiroshi ImaiDepartment of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.ORCID 0000-0001-8939-2255
Akira NogaLaboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.
Jagan Mohan ObbineniLaboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.ORCID 0000-0001-7716-2778
Noemi ZimmermannLaboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.ORCID 0000-0002-7027-0028
Masako NakajimaLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan.ORCID 0000-0001-5385-9482
Daisuke ShibataShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.
Misa ShibataShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.ORCID 0000-0002-7995-5322
Kogiku ShibaShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.ORCID 0000-0002-7742-8158
Masaki KitaFaculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan.ORCID 0000-0001-6685-4461
Hideo KigoshiFaculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan.ORCID 0000-0003-1554-5129
Yui TanakaDepartment of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
Yuya YamasakiDepartment of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
Yuma AsahinaLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan.
Chihong SongNational Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.
Mami NomuraShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.ORCID 0000-0002-8966-2400
Mamoru NomuraShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.
Ayako NakajimaShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.
Mia NakachiShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan.
Lixy YamadaSugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Toba, Mie 517-0004, Japan.
Shiori NakazawaSugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Toba, Mie 517-0004, Japan.ORCID 0000-0001-8179-5420
Hitoshi SawadaSugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Toba, Mie 517-0004, Japan.
Kazuyoshi MurataNational Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.ORCID 0000-0001-9446-3652
Kaoru MitsuokaResearch Center for Ultra-High Voltage Electron Microscopy, Osaka University, Ibaraki, Osaka 567-0047, Japan.ORCID 0000-0003-1782-675X
Takashi IshikawaLaboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.
Ken-Ichi WakabayashiLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan.
Takahide KonDepartment of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.ORCID 0000-0002-1231-7609
Kazuo InabaShimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka 415-0025, Japan. kinaba@shimoda.tsukuba.ac.jp.ORCID 0000-0001-8848-9733
University of Tsukuba · JPThe University of Osaka · JPPaul Scherrer Institute · CHNagoya University · JPTokyo Institute of Technology · JPNational Institutes of Natural Sciences · JPNational Institute of Advanced Industrial Science and Technology · JPUniversity of Fukui · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule.

Identifiers

PMID33637535
PMCPMC7909887
OpenAlexW3129219808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.