Evidence map›Paper›PMID 33637534›Full record

ArticleScience advances2021

Molecular architecture of the endocytic TPLATE complex.

Klaas Yperman, Jie Wang, Dominique Eeckhout, Joanna Winkler, Lam Dai Vu, Michael Vandorpe, Peter Grones, Evelien Mylle, Michael Kraus, Romain Merceron and 10 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. LUMINIDEPENDENS orchestrates global transcriptional repression inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  5. Review
  6. Review
  7. Exploring lipid-protein interactions in plant membranes.Journal of experimental botany · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. A SNARE-like protein fromFrontiers in plant science · 2023
    Article
  14. Article
  15. Article
  16. TheeLife · 2022
    Article
  17. Review
  18. Review
  19. The TPLATE complex mediates membrane bending during plant clathrin-mediated endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Klaas YpermanDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0002-7542-1155
Jie WangDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0002-8076-0995
Dominique EeckhoutDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0001-5770-7670
Joanna WinklerDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0001-6565-6279
Lam Dai VuDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0001-5078-7532
Michael VandorpeDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0001-8936-4174
Peter GronesDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0003-4132-4151
Evelien MylleDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.
Michael KrausDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0003-0186-1497
Romain MerceronDepartment of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium.
Jonah NolfDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0002-4393-0852
Eliana MorDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0002-4743-8865
Pieter De BruynVrije Universiteit Brussel, Structural Biology Brussels, Department of Biotechnology, 1050 Brussels, Belgium.ORCID 0000-0001-7126-6103
Remy LorisVIB-VUB Center for Structural Biology, Structural Biology Research Center, Molecular Recognition Unit, 1050 Brussels, Belgium.ORCID 0000-0002-8862-3338
Martin PotockýInstitute of Experimental Botany, Academy of Sciences of the Czech Republic, Rozvojová 263, 16502 Prague 6, Czech Republic.ORCID 0000-0002-3699-7549
Savvas N SavvidesDepartment of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0003-3420-5947
Bert De RybelDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0002-9551-042X
Geert De JaegerDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.ORCID 0000-0001-6558-5669
Daniël Van DammeDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium. daniel.vandamme@psb.vib-ugent.be pleskot@ueb.cas.cz.ORCID 0000-0002-9385-4851
Roman PleskotDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 71, 9052 Ghent, Belgium. daniel.vandamme@psb.vib-ugent.be pleskot@ueb.cas.cz.ORCID 0000-0003-0436-9748
Ghent University · BECzech Academy of Sciences, Institute of Experimental Botany · CZVIB-VUB Center for Structural Biology · BEVrije Universiteit Brussel · BE

Funding

European Research Council 682436
6 · The paper itself

Abstract

Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as an endocytic regulator. Unlike other coatomer complexes, structural insight into TSET is lacking. Here, we reveal the molecular architecture of plant TSET [TPLATE complex (TPC)] using an integrative structural approach. We identify crucial roles for specific TSET subunits in complex assembly and membrane interaction. Our data therefore generate fresh insight into the differences between the hexameric TSET in

Identifiers

PMID33637534
PMCPMC7909872
OpenAlexW3133457885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.