ArticleScience advances2021
Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Three weeks of mental training changes physiological outcomes during a time trial to exhaustion.European journal of applied physiology · 2023Trial
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- Article
- Assessing the role of BNST GABA neurons in backward conditioned suppression.Neurobiology of learning and memory · 2025Article
- Role of the bed nucleus of the stria terminalis in feeding.Frontiers in nutrition · 2025Review
- Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception.National science review · 2024Article
- Glutamatergic supramammillary nucleus neurons respond to threatening stressors and promote active coping.eLife · 2024Article
- Sex-specific negative affect-like behaviour and parabrachial nucleus activation induced by BNST stimulation in adult mice with adolescent alcohol history.Addiction biology · 2024Article
- Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development.bioRxiv : the preprint server for biology · 2024Article
- Negative Emotions Recruit the Parabrachial Nucleus Efferent to the VTA to Disengage Instrumental Food Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Recruitment of Hippocampal and Thalamic Pathways to the Central Amygdala in the Control of Feeding Behavior Under Novelty.Research square · 2023Article
- A sex-specific role for the bed nucleus of the stria terminalis in proactive defensive behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Activation of Parabrachial Tachykinin 1 Neurons Counteracts Some Behaviors Mediated by Parabrachial Calcitonin Gene-related Peptide Neurons.Neuroscience · 2023Article
- Review
- Emerging approaches for decoding neuropeptide transmission.Trends in neurosciences · 2022Review
- Molecular and anatomical characterization of parabrachial neurons and their axonal projections.eLife · 2022Article
- Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus.Brain structure & function · 2022Article
- GABAergic CaMKIIα+ Amygdala Output Attenuates Pain and Modulates Emotional-Motivational Behavior via Parabrachial Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression.eLife · 2022Article
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
An animal's evolutionary success depends on the ability to seek and consume foods while avoiding environmental threats. However, how evolutionarily conserved threat detection circuits modulate feeding is unknown. In mammals, feeding and threat assessment are strongly influenced by the parabrachial nucleus (PBN), a structure that responds to threats and inhibits feeding. Here, we report that the PBN receives dense inputs from two discrete neuronal populations in the bed nucleus of the stria terminalis (BNST), an extended amygdala structure that encodes affective information. Using a series of complementary approaches, we identify opposing BNST-PBN circuits that modulate neuropeptide-expressing PBN neurons to control feeding and affective states. These previously unrecognized neural circuits thus serve as potential nodes of neural circuitry critical for the integration of threat information with the intrinsic drive to feed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.