Evidence map›Paper›PMID 33637194›Full record

ArticleKidney international2021

Rationale and design of the Kidney Precision Medicine Project.

Ian H de Boer, Charles E Alpers, Evren U Azeloglu, Ulysses G J Balis, Jonathan M Barasch, Laura Barisoni, Kristina N Blank, Andrew S Bomback, Keith Brown, Pierre C Dagher and 41 more

Registry-linked trialAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04334707 (Kidney Precision Medicine Project), which is not on this map. Cited by 104 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04334707 recruitingnot on this map

Kidney Precision Medicine Project

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2019 to 2027Enrolled1,000ConditionsAcute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal InjuryArmsKidney Biopsy, MRI, Retina Scan
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
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  12. Review
  13. Deciphering the Impact of RAC1-SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  14. Article
  15. Review
  16. Article
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

Ian H de BoerDepartment of Medicine, University of Washington, Seattle, Washington, USA. Electronic address: deboer@u.washington.edu.
Charles E AlpersDepartment of Pathology, University of Washington, Seattle, Washington, USA.
Evren U AzelogluDepartment of Medicine, Icahn School of Medicine at Mt. Sinai, New York, New York, USA.
Ulysses G J BalisDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Jonathan M BaraschDepartment of Pathology, Columbia University, New York, New York, USA.
Laura BarisoniDepartment of Pathology, Duke University, Durham, North Carolina, USA.
Kristina N BlankDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Andrew S BombackDepartment of Medicine, Columbia University, New York, New York, USA.
Keith BrownPatient Representative, Kidney Precision Medicine Project Steering Committee Member.
Pierre C DagherDepartment of Medicine, Indiana University, Indianapolis, Indiana, USA.
Ashveena L DigheDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Michael T EadonDepartment of Medicine, Indiana University, Indianapolis, Indiana, USA.
Tarek M El-AchkarDepartment of Medicine, Indiana University, Indianapolis, Indiana, USA.
Joseph P GautDepartment of Pathology, Washington University School of Medicine, St. Louis, St. Louis, Missouri, USA.
Nir HacohenBroad Institute, Cambridge, Massachusetts, USA.
Yongqun HeDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Jeffrey B HodginDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Sanjay JainDepartment of Medicine, Washington University School of Medicine, St. Louis, St. Louis, Missouri, USA.
John A KellumDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Krzysztof KirylukDepartment of Medicine, Columbia University, New York, New York, USA.
Richard KnightAmerican Association of Kidney Patients, Kidney Precision Medicine Project Patient Partner.
Zoltan G LaszikDepartment of Pathology, University of California, San Francisco, San Francisco, California, USA.
Chrysta LienczewskiDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Laura H MarianiDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Robyn L McClellandDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Steven MenezDepartment of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Dennis G MoledinaDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Sean D MooneyDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA.
John F O'TooleDepartment of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.
Paul M PalevskyRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Renal Section, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Chirag R ParikhDepartment of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Emilio D PoggioDepartment of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.
Sylvia E RosasJoslin Diabetes Center, Boston, Massachusetts, USA.
Matthew R RosengartDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Minnie M SarwalDepartment of Surgery, University of California, San Francisco, San Francisco, California, USA.
Jennifer A SchaubDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
John R SedorDepartment of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.
Kumar SharmaDepartment of Medicine, UT Health San Antonio, San Antonio, Texas, USA.
Becky SteckDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Robert D TotoDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Olga G TroyanskayaDepartment of Computer Science, Princeton University, Princeton, New Jersey, USA.
Katherine R TuttleDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Miguel A VazquezDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Sushrut S WaikarDepartment of Medicine, Boston University Medical Center, Boston, Massachusetts, USA.
Kayleen WilliamsDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Francis Perry WilsonDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Kun ZhangInstitute for Genomic Sciences, University of California, San Diego, California, USA.
Ravi IyengarMount Sinai Institute for Systems Biomedicine, Mount Sinai, New York, New York, USA.
Matthias KretzlerRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jonathan HimmelfarbDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Kidney Precision Medicine Project

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI Alessandro Doria · 1986 to 2026
$50.5M
Central Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1M
ConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2017 to 2021
$21.0M
PROBE DELIVERY COREP30DK079312 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MOLITORIS, BRUCE A · 2007 to 2021
$17.1M
PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)U01DK114907 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nir Hacohen, Jeffrey Benton Hodgin · 2022 to 2026
$3.2M
Spatial Metabolomics for Human KidneysUH3DK114920 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHARMA, KUMAR · 2019 to 2021
$2.7M
Nephron Sub-segmental Omics and Quantitative 3D Imaging of Human Kidney.UH3DK114923 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ASHKAR, TAREK MAURICE, DAGHER, PIERRE C · 2019 to 2021
$2.2M
PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)UH3DK114907 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HACOHEN, NIR, HODGIN, JEFFREY BENTON · 2019 to 2021
$1.8M
Single-nucleus sequencing and in situ mapping of mRNA molecules in human kidneyUH3DK114933 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, SANJAY, ZHANG, KUN · 2019 to 2021
$1.8M
Multidimensional cellular interrogation of the kidney in AKI and CKDUH3DK114937 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LASZIK, ZOLTAN · 2019 to 2021
$1.2M
Kidney Precision Medicine Program (KPMP): Columbia AKI Recruitment SiteUH3DK114926 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARASCH, JONATHAN M., BOMBACK, ANDREW STEPHEN · 2019 to 2021
$900k
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS K08 DK107864NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK079312NIDDK NIH HHS U01 DK114907NIDDK NIH HHS U24 DK114886NIDDK NIH HHS U2C DK114886NIDDK NIH HHS UG3 DK114861NIDDK NIH HHS UH3 DK114861NIDDK NIH HHS UH3 DK114866NIDDK NIH HHS UH3 DK114870NIDDK NIH HHS UH3 DK114907NIDDK NIH HHS UH3 DK114908NIDDK NIH HHS UH3 DK114915NIDDK NIH HHS UH3 DK114920NIDDK NIH HHS UH3 DK114923NIDDK NIH HHS UH3 DK114926NIDDK NIH HHS UH3 DK114933NIDDK NIH HHS UH3 DK114937
6 · The paper itself

Abstract

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

Indexed as

Acute Kidney InjuryRenal Insufficiency, ChronicAdultHumansKidneyMulticenter Studies as TopicPrecision MedicineProspective StudiesProteomicsacute kidney injurychronic kidney diseasediabeteshypertensionprecision medicine

Identifiers

PMID33637194
PMCPMC8330551

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.