Evidence map›Paper›PMID 33637118›Full record

ArticleCell communication and signaling : CCS2021

Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity.

Jason D Domogauer, Sonia M de Toledo, Roger W Howell, Edouard I Azzam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jason D DomogauerDivision of Radiation Research and Center for Cell Signaling, Department of Radiology, Rutgers Biomedical and Health Sciences, New Jersey Medical School, Rutgers University, 205 South Orange Avenue, Room - F1212, Newark, NJ, USA.
Sonia M de ToledoDivision of Radiation Research and Center for Cell Signaling, Department of Radiology, Rutgers Biomedical and Health Sciences, New Jersey Medical School, Rutgers University, 205 South Orange Avenue, Room - F1212, Newark, NJ, USA.
Roger W HowellDivision of Radiation Research and Center for Cell Signaling, Department of Radiology, Rutgers Biomedical and Health Sciences, New Jersey Medical School, Rutgers University, 205 South Orange Avenue, Room - F1212, Newark, NJ, USA.
Edouard I AzzamDivision of Radiation Research and Center for Cell Signaling, Department of Radiology, Rutgers Biomedical and Health Sciences, New Jersey Medical School, Rutgers University, 205 South Orange Avenue, Room - F1212, Newark, NJ, USA. edouard.azzam@rutgers.edu.ORCID 0000-0002-8968-1142
Rutgers, The State University of New Jersey · US

Funding

THE FUNCTIONAL GENOMICS OF BYSTANDER RESPONSESP01CA049062 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HEI, TOM K. · 1990 to 2014
$21.9M
NCI NIH HHS P01 CA049062NIH HHS CA049062State of New Jersey Department of Human Services DFHS13PPCO17
6 · The paper itself

Abstract

backgroundCancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique characteristics that enhance their resistance to ionizing radiation.

methodsCAFs were generated through intimate coculture of normal human fibroblasts of skin or lung origin with various human cancer cell types using permeable microporous membrane inserts. Fibroblasts and cancer cells are grown intimately, yet separately, on either side of the insert's membrane for extended times to generate activated fibroblast populations highly enriched in CAFs.

resultsThe generated CAFs exhibited a decrease in Caveolin-1 protein expression levels, a CAF biomarker, which was further enhanced when the coculture was maintained under in-vivo-like oxygen tension conditions. The level of p21

conclusionsThis study reveals that CAFs are radioresistant and experience significant changes in indices of oxidative metabolism. The CAFs that survive radiation treatment likely modulate the fate of the associated cancer cells. Identifying them together with their mode of communication with cancer cells, and eradicating them, particularly when they may exist at the margin of the radiotherapy planning target volume, may improve the efficacy of cancer treatments. Video Abstract.

Indexed as

DNA RepairRadiation ToleranceAntioxidantsCancer-Associated FibroblastsCaveolin 1Cell CommunicationCell Line, TumorCellular SenescenceChromosomes, HumanCoculture TechniquesCyclin-Dependent Kinase Inhibitor p21DNA Breaks, Double-StrandedDNA Breaks, Single-StrandedGenomic InstabilityHumansNeoplasmsAntioxidantsCaveolin 1Cyclin-Dependent Kinase Inhibitor p21Superoxide DismutaseCancer associated fibroblastsDNA repairIntercellular communicationOxidative metabolismRadioresistanceRadiotherapy

Identifiers

PMID33637118
PMCPMC7912493
OpenAlexW3116283541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.