Observational studyBMC musculoskeletal disorders2021
Fragility fracture identifies patients at imminent risk for subsequent fracture: real-world retrospective database study in Ontario, Canada.
Observational study in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recommendations on screening for primary prevention of fragility fractures.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Guideline
- Second contralateral hip fractures reduce survival, mobility and daily activity : a matched pair analysis.Archives of orthopaedic and trauma surgery · 2026Article
- Impact of a national reimbursement add-on policy on refracture risk and secondary fracture prevention after hip fracture in Japan: a population-based interrupted time series analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Risk factors in elderly female patients for refracture within two years following surgery for fragility fractures: a prospective observational study.Archives of osteoporosis · 2026Observational
- Letter to the editor.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- The added value of distal radius bone mineral density for the diagnosis of osteoporosis in patients with a history of fragility fracture.BMC musculoskeletal disorders · 2025Article
- The role of physical performance measures in the physiotherapy assessment and management of older adults with osteoporotic vertebral fractures: a narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Osteoporosis treatment gap after hip fracture: data from a tertiary center in Turkey.Archives of osteoporosis · 2025Article
- Clinical Validation of Commercial AI Software for the Detection of Incidental Vertebral Compression Fractures in CT Scans of the Chest and Abdomen.Diagnostics (Basel, Switzerland) · 2025Article
- Bone Health, Fragility Fractures, and the Hand Surgeon.Journal of hand surgery global online · 2025Review
- First fracture in rheumatoid arthritis: analysis by fracture site, gender, age, and comorbidities.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Cost-effectiveness analysis of romosozumab for severe postmenopausal osteoporosis at very high risk of fracture in Mexico.PloS one · 2025Article
- Fracture liaison service-a multidisciplinary approach to osteoporosis management.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Review
- The predictive value of albumin to alkaline phosphatase ratio for vertebral refractures in postmenopausal women.Journal of bone and mineral metabolism · 2024Article
- Following hip fracture, hospital organizational factors associated with prescription of anti-osteoporosis medication on discharge, to address imminent refracture risk: a record-linkage study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Risk of Subsequent Hip Fractures across Varying Treatment Patterns for Index Vertebral Compression Fractures.Journal of clinical medicine · 2024Article
- Family/caregiver influence on osteoporosis management for older people: an integrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Review
- Risk analysis for subsequent fracture of osteoporotic fractures in Chinese women over age 60: a nationwide cross-sectional study.Scientific reports · 2024Article
- Postfracture survival in a population-based study of adults aged ≥66 yr: a call to action at hospital discharge.JBMR plus · 2024Article
- Development and Comparison of Treatment Decision Tools for Glucocorticoid-Induced Osteoporosis.Diagnostics (Basel, Switzerland) · 2024Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe secondary fracture prevention gap in the osteoporosis field has been previously described as a 'crisis'. Closing this gap is increasingly important in the context of accumulating evidence showing that an incident fragility fracture is associated with an increased risk of subsequent fracture within 1-2 years, known as imminent fracture risk. The objective of this study was to use health services data to characterize the time between index fragility fractures occurring at different osteoporotic sites and subsequent fractures.
methodsThis retrospective observational study used de-identified health services data from the publicly funded healthcare system in Ontario, the largest province of Canada. Patients aged > 65 with an index fragility fracture occurring between 2011 and 2015 were identified from the ICES Data Repository using International Classification of Diseases (ICD)-10 codes. We examined median time to subsequent fragility fractures for osteoporotic fracture sites until the end of follow-up (2017). BMD assessment and use of osteoporosis therapies following index fracture were also characterized.
resultsAmong 115,776 patients with an index fragility fracture, 17.8% incurred a second fragility fracture. Median time between index and second fracture occurring at any site was 555 days (interquartile range: 236-955). For each index fracture site examined, median time from index to second fracture was < 2 years. The proportion of patients with BMD assessment was 10.3% ≤1 year prior to and 16.4% ≤1 year post index fracture. The proportion of patients receiving osteoporosis therapy was 29.8% ≤1 year prior, 34.6% ≤1 year post, and 25.9% > 3 years post index fracture.
conclusionsThis cohort of Canadian patients aged > 65 years who experienced a fragility fracture at any site are at imminent risk of experiencing subsequent fracture within the next 2 years and should be proactively assessed and treated.
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