ArticleNeuroImage. Clinical2021
Disrupted brain connectivity in children treated with therapeutic hypothermia for neonatal encephalopathy.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art.Pediatric research · 2025Review
- Shifting outlooks after neonatal encephalopathy in the era of therapeutic hypothermia.Pediatric research · 2025Review
- Cooling and physiology during parent cuddling infants with neonatal encephalopathy in usual care: CoolCuddle-2 study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Slow rewarming after hypothermia does not ameliorate white matter injury after hypoxia-ischemia in near-term fetal sheep.Pediatric research · 2025Article
- Oligodendrocyte progenitor cells' fate after neonatal asphyxia-Puzzling implications for the development of hypoxic-ischemic encephalopathy.Brain pathology (Zurich, Switzerland) · 2024Article
- Neuroprotective Effect of Clemastine Improved Oligodendrocyte Proliferation through the MAPK/ERK Pathway in a Neonatal Hypoxia Ischemia Rat Model.International journal of molecular sciences · 2024Article
- Resting-state functional connectivity in children cooled for neonatal encephalopathy.Brain communications · 2024Article
- Cerebellar growth, volume and diffusivity in children cooled for neonatal encephalopathy without cerebral palsy.Scientific reports · 2023Article
- Mammillary body abnormalities and cognitive outcomes in children cooled for neonatal encephalopathy.Developmental medicine and child neurology · 2023Article
- Outcome at early school age and adolescence after hypothermia-treated hypoxic-ischaemic encephalopathy: an observational, population-based study.Archives of disease in childhood. Fetal and neonatal edition · 2023Observational
- Long-term consequences of neonatal encephalopathy in the hypothermia era: protocol for a follow-up cohort study at 9 years of age.BMJ open · 2023Article
- Brain volumes and functional outcomes in children without cerebral palsy after therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy.Developmental medicine and child neurology · 2023Article
- Development of the corpus callosum and cognition after neonatal encephalopathy.Annals of clinical and translational neurology · 2023Article
- Communication skills in children aged 6-8 years, without cerebral palsy cooled for neonatal hypoxic-ischemic encephalopathy.Scientific reports · 2022Article
- Neonatal brain injury influences structural connectivity and childhood functional outcomes.PloS one · 2022Article
- Physiological responses to cuddling babies with hypoxic-ischaemic encephalopathy during therapeutic hypothermia: an observational study.BMJ paediatrics open · 2021Observational
- Melatonin for Neonatal Encephalopathy: From Bench to Bedside.International journal of molecular sciences · 2021Review
- Motor function and white matter connectivity in children cooled for neonatal encephalopathy.NeuroImage. Clinical · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Therapeutic hypothermia following neonatal encephalopathy due to birth asphyxia reduces death and cerebral palsy. However, school-age children without cerebral palsy treated with therapeutic hypothermia for neonatal encephalopathy still have reduced performance on cognitive and motor tests, attention difficulties, slower reaction times and reduced visuo-spatial processing abilities compared to typically developing controls. We acquired diffusion-weighted imaging data from school-age children without cerebral palsy treated with therapeutic hypothermia for neonatal encephalopathy at birth, and a matched control group. Voxelwise analysis (33 cases, 36 controls) confirmed reduced fractional anisotropy in widespread areas of white matter in cases, particularly in the fornix, corpus callosum, anterior and posterior limbs of the internal capsule bilaterally and cingulum bilaterally. In structural brain networks constructed using probabilistic tractography (22 cases, 32 controls), graph-theoretic measures of strength, local and global efficiency, clustering coefficient and characteristic path length were found to correlate with IQ in cases but not controls. Network-based statistic analysis implicated brain regions involved in visuo-spatial processing and attention, aligning with previous behavioural findings. These included the precuneus, thalamus, left superior parietal gyrus and left inferior temporal gyrus. Our findings demonstrate that, despite the manifest successes of therapeutic hypothermia, brain development is impaired in these children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.