Evidence map›Paper›PMID 33636344›Full record

ArticleContemporary clinical trials2021

The protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges.

Marcella A Kelley, Stephen D Persell, Jeffrey A Linder, Mark W Friedberg, Daniella Meeker, Craig R Fox, Noah J Goldstein, Tara K Knight, Dina Zein, Theresa A Rowe and 2 more

3 registry-linked trialsAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03773484 nacompletednot on this map

Application of Economics & Social Psychology to Improve Opioid Prescribing Safety (AESOPS): R21 Pilot Phase

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2019 to 2019Enrolled41ConditionsOpioid Use, UnspecifiedArmsOpioid naive, At-risk for long term use, Long-term opioid recipient
NCT04477304 nacompletednot on this map

Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 1: Electronic Health Record Nudges

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2020 to 2023Enrolled555ConditionsOpioid Abuse, UnspecifiedArmsOpioid Naive, OR, At-risk for long-term use, OR, Long-term opioid recipient
NCT07397260 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Effects of Manually Recorded or Automatically Transmitted Home Blood Pressures With or Without Automated Patient Feedback on Hypertension Care

TypeinterventionalSponsorNorthwestern UniversityRan2026 to 2028Enrolled1,304ConditionsHypertension (HTN)ArmsSelf report of home measured blood pressure via patient EHR portal, Automated feedback about home blood pressure results, Automated Transmission of Remotely Measured Blood Pressure
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marcella A KelleySchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America; School of Pharmacy, University of Southern California, Los Angeles, CA, United States of America.
Stephen D PersellDivision of General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Jeffrey A LinderDivision of General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Mark W FriedbergBlue Cross Blue Shield of Massachusetts, Boston, MA, United States of America.
Daniella MeekerSchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America; Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
Craig R FoxAnderson School of Management, University of California at Los Angeles, Los Angeles, CA, United States of America.
Noah J GoldsteinAnderson School of Management, University of California at Los Angeles, Los Angeles, CA, United States of America.
Tara K KnightSchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America; Sol Price School of Public Policy, University of Southern California, Los Angeles, CA, United States of America.
Dina ZeinSchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America.
Theresa A RoweDivision of General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Mark D SullivanSchool of Medicine, University of Washington, School of Medicine, Seattle, WA, United States of America.
Jason N DoctorSchaeffer Center for Health Economics and Policy, University of Southern California, Los Angeles, CA, United States of America; School of Pharmacy, University of Southern California, Los Angeles, CA, United States of America; Sol Price School of Public Policy, University of Southern California, Los Angeles, CA, United States of America. Electronic address: jdoctor@usc.edu.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
USC-Yale Roybal Center for Behavioral Interventions in AgingP30AG024968 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JASON N. DOCTOR, Daniella Meeker · 2004 to 2026
$14.7M
Use of Behavioral Economics in Repeat SARS-CoV-2 Antibody Testing in Disadvantaged CommunitiesR33AG057395 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DOCTOR, JASON N., SULLIVAN, MARK D · 2019 to 2021
$3.3M
Application of Economics & Social psychology to improve Opioid Prescribing Safety (AESOPS) TrialR21AG057395 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DOCTOR, JASON N., SULLIVAN, MARK D · 2017 to 2018
$494k
NCATS NIH HHS UL1 TR001422NIA NIH HHS P30 AG024968NIA NIH HHS R21 AG057395NIA NIH HHS R33 AG057395
6 · The paper itself

Abstract

backgroundThere is a lack of evidence that long-term opioid use offers benefit for noncancer pain and an abundance of evidence of harm. Despite clinical guidelines and education, prescribing continues at a higher rate than before the opioids crisis. The objective of trial 1 of the Application of Economics & Social psychology to improve Opioid Prescribing Safety (AESOPS-1) is to discourage unnecessary opioid prescribing in primary care by applying "behavioral insights"-empirically-tested social and psychological interventions that affect choice.

methodsAESOPS-1 randomizes primary care clinics in Illinois and California to behavioral intervention or control. Both arms receive opioid guideline education. Clinics randomized to the behavioral intervention arm receive nudges within the electronic health record (EHR) including: 1) an "accountable justification" entered in the chart, 2) a precommitment to address high-risk prescriptions, and 3) a "PainTracker" that broadens discussions about pain. The control arm receives no EHR-based intervention. The primary outcome is the change in weekly milligram morphine equivalents (MME) prescribed. The secondary outcome is the change in the proportion of patients prescribed at least 50 daily MME. To evaluate these outcomes, we will use a difference-in-differences mixed-effects regression model on clinician MME weekly or daily dose. The analysis will be "intent-to-treat." The intervention period is 18-months, with a 6-month follow-up period to measure persistence of effects. DISCUSSION: The AESOPS-1 trial will evaluate the effect of EHR-based interventions in reducing noncancer opioid prescribing in primary care. AESOPS-1 may demonstrate practical and scalable strategies to lower unnecessary population exposure to opioids.

Indexed as

Analgesics, OpioidOpioid-Related DisordersElectronic Health RecordsHumansPractice Patterns, Physicians'Psychology, SocialRandomized Controlled Trials as TopicAnalgesics, OpioidBehavioral economicsNudgesOpioid use disorderRandomized controlled trial

Identifiers

PMID33636344
PMCPMC8089040

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.