ArticleEnvironmental research2021
Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction.
Article in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 117 citations in OpenAlex.
- Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine.American journal of physiology. Heart and circulatory physiology · 2024Trial
- Community-Based Evaluation of the Associations Between Well-Being and Cardiovascular Disease Risk.Journal of the American Heart Association · 2022Trial
- Associations between volatile organic compound mixtures and allostatic load: Evidence from the Green Heart Louisville Project.Environmental research · 2026Article
- A Perfect Storm of Pollutants: Environmental Mixtures in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2026Review
- Article
- Association of volatile organic compounds with serum lactate dehydrogenase levels in the general adults.International archives of occupational and environmental health · 2026Article
- A unified liquid chromatography-mass spectrometric approach combining targeted and untargeted analyses for community exposure profiling in wastewater.Environment international · 2026Article
- Plain Language Summarization of Environmental Health Research Using Generative AI: Community-Engaged Qualitative Study.Journal of medical Internet research · 2026Article
- Urinary metabolites of 1,3-butadiene, benzene and toluene and colorectal cancer incidence: a clinical case-control study.Cancer causes & control : CCC · 2026Article
- A Population-Centered Health Framework for Analyzing Superfund Sites With a History of Volatile Organic Compound Contamination.Community health equity research & policy · 2026Article
- Associations of sympathetic activation with exposure to volatile organic compounds: A cross-sectional study.Environmental research · 2025Article
- Machine learning prediction of osteoarthritis risk from volatile organic compound exposure using SHAP interpretation in US adults.Scientific reports · 2025Article
- Blood concentrations of volatile organic compounds and hypertension in the GuLF Study.The Science of the total environment · 2025Article
- Article
- Heart failure in water pipe smokers: a review of evidence on ventricular dysfunction, oxidative stress, and inflammatory pathways.Annals of medicine and surgery (2012) · 2025Review
- Characterizing everyday exposure to volatile organic compounds and upper respiratory health effects.Scientific reports · 2025Article
- Correlation of exposure to volatile organic compounds with myocardial infarction: A Cross-sectional study based on NHANES 2011-2018.Scientific reports · 2025Article
- Simultaneous profiling of mercapturic acids, glucuronic acids, and sulfates in human urine.Environment international · 2025Article
- Association between exposure to volatile organic compounds and atherogenic index of plasma in NHANES 2011-2018.Scientific reports · 2025Article
- Volatile organic compounds exposure associated with skin cancer among U. S. adults: results from NHANES 2011-2018.Archives of dermatological research · 2025Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCardiovascular disease (CVD) is the leading cause of mortality worldwide. Exposure to air pollution, specifically particulate matter of diameter ≤2.5 μm (PM
objectiveTo examine the vascular effects of exposure to individual volatile organic compounds (VOCs) and mixtures of VOCs.
methodsWe measured urinary metabolites of acrolein (CEMA and 3HPMA), 1,3-butadiene (DHBMA and MHBMA3), and crotonaldehyde (HPMMA) in 346 nonsmokers with varying levels of CVD risk. On the day of enrollment, we measured blood pressure (BP), reactive hyperemia index (RHI - a measure of endothelial function), and urinary levels of catecholamines and their metabolites. We used generalized linear models for evaluating the association between individual VOC metabolites and BP, RHI, and catecholamines, and we used Bayesian Kernel Machine Regression (BKMR) to assess exposure to VOC metabolite mixtures and BP.
resultsWe found that the levels of 3HPMA were positively associated with systolic BP (0.98 mmHg per interquartile range (IQR) of 3HPMA; CI: 0.06, 1.91; P = 0.04). Stratified analysis revealed an increased association with systolic BP in Black participants despite lower levels of urinary 3HPMA. This association was independent of PM DISCUSSION: Exposure to acrolein and 1,3-butadiene is associated with endothelial dysfunction and may contribute to elevated risk of hypertension in participants with increased sympathetic tone, particularly in Black individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.