ArticleCell2021
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8
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Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
110 citing papers in PubMed, 139 citations in OpenAlex.
- Murine IL-2 outperforms human IL-2 in supporting the survival of naïve mouse CD8 T cells in vitro.Life science alliance · 2026Article
- Methionine Regulates Antitumour Function of CD8Immunology · 2026Article
- Article
- Metabolic profiling of CAR T-cells in patients reveals a shift toward amino acid-supported OXPHOS and informs transporter engineering.Research square · 2026Article
- High-Content CRISPR Screening: Methods and Applications.MedComm · 2026Review
- GRP75 sustains CD8Cell death and differentiation · 2026Article
- Multiomic analysis identifies glutaminolysis-dependent metabolic enhancement of immune memory utilised for vaccine development.Nature communications · 2026Article
- A community machine learning challenge to predict the effects of gene perturbations on T cell differentiation for cancer immunotherapy.bioRxiv : the preprint server for biology · 2026Article
- Solute carrier transporters as metabolic gatekeepers in tumor-microenvironment crosstalk.Acta pharmacologica Sinica · 2026Review
- Distinct cytokines regulate gene expression and anti-tumor activity in regenerated CD8iScience · 2026Article
- Metabolic and transcriptional plasticity supports CD8Immunity · 2026Article
- Metabolic modulation of immune cell function: mechanisms and therapeutic implications in cancer immunotherapy.Oncogenesis · 2026Review
- Spatial instruction of tissue immunity.ImmunoHorizons · 2026Review
- Solute Carrier transporters in tumor metabolism and immune modulation: implications for therapy.Journal of translational medicine · 2026Review
- In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation.The Journal of experimental medicine · 2026Article
- Targeting organelle function in T cells for cancer immunotherapy.Nature reviews. Immunology · 2026Review
- Targeting metabolic reprogramming to enhance adoptive immunotherapy: emerging mechanisms and translational perspectives.Journal of translational medicine · 2026Review
- Optimal transport fate mapping resolves T cell differentiation dynamics across tissues.bioRxiv : the preprint server for biology · 2026Article
- Clonally expanded HSP-specific T cells contribute to glaucomatous neurodegeneration via the mTORC1 pathway.Journal of neuroinflammation · 2026Article
- Tumor-immune metabolic tug-of-war: from immune escape to targeting metabolic rewiring in cancer therapy.Frontiers in cell and developmental biology · 2026Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Hongling HuangDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peipei ZhouDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jun WeiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lingyun LongDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hao ShiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yogesh DhunganaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Nicole M ChapmanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Guotong FuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jordy SaraviaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jana L RaynorDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Shaofeng LiuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Gustavo PalaciosDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yong-Dong WangDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Chenxi QianDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jiyang YuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: hongbo.chi@stjude.org.
St. Jude Children's Research Hospital · US
Funding
Regulation of TH17 plasticity and stemness by mTORC1R01AI131703 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$4.1MTranscriptional and metabolic heterogeneity in T cell differentiationR01AI140761 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$3.9MMetabolic checkpoint in dendritic cell subsets and adaptive immunityR37AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.6MBidirectional signaling in T cell differentiationR01AI150241 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.3MNutrient sensing and lysosomal signaling in regulatory T cells and immune toleranceR01AI150514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2019 to 2023
$2.2MMetabolic checkpoint in TH17 cell differentiationR01AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$2.2MTsc1/mTOR axis in immune homeostasis and tumorigenesisR01CA176624 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$1.9MIntracellular and Intercellular Network Rewiring and Hidden Driver Inference from Single-Cell DataR01GM134382 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YU, JIYANG · 2019 to 2023
$1.7MMetabolic reprogramming of Tregs in tumor immunityR01CA221290 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2017 to 2020
$1.6MReprogram long-lived effector T cells for cancer immunotherapyR01CA250533 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2020 to 2021
$1.2MNCI NIH HHS R01 CA176624NCI NIH HHS R01 CA221290NCI NIH HHS R01 CA250533NIAID NIH HHS R01 AI105887NIAID NIH HHS R01 AI131703NIAID NIH HHS R01 AI140761NIAID NIH HHS R01 AI150241NIAID NIH HHS R01 AI150514NIAID NIH HHS R37 AI105887NIGMS NIH HHS R01 GM134382
Abstract
How early events in effector T cell (T
Indexed as
Immunologic MemorySignal TransductionAmino AcidsAmino Acid Transport SystemsAnimalsCD8-Positive T-LymphocytesCell CycleCell DifferentiationCRISPR-Cas SystemsDisease Models, AnimalFemaleGene Knock-In TechniquesLymphocytic ChoriomeningitisMaleMiceMice, TransgenicAmino AcidsAmino Acid Transport Systemscell cycle exitGDP-fucoseimmunometabolismin vivo pooled CRISPR screeningmetabolic heterogeneityNotchnutrient signalingsystems immunologyT cell memoryterminal effector cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.