ArticleCell2021
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 223 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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223citing papers in PubMed, 1 pooled it
23.3field-weighted citation impact, top 1% of its field
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Who cites it
223 citing papers in PubMed, 1 synthesis or guideline pooled it, 392 citations in OpenAlex.
- Clinical Data for Parametrization ofFrontiers in bioengineering and biotechnology · 2022Pooled it
- Multiple Vertebral Fractures After Denosumab Discontinuation: FREEDOM and FREEDOM Extension Trials Additional Post Hoc Analyses.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Trial
- Effects of denosumab treatment on the expression of receptor activator of nuclear kappa-B ligand (RANKL) and TNF-receptor TNFRSF9 after total hip arthroplasty-results from a randomized placebo-controlled clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Trial
- Article
- Short-chain fatty acids promote post-myocardial infarction cardiac repair via FFAR2-dependent suppression of osteoclast-like macrophage differentiation.Basic research in cardiology · 2026Article
- Osteoprotegerin and receptor activator of NF-kappaB ligand as biomarkers for bone resorption-related disorders.World journal of experimental medicine · 2026Review
- BCAT2 links branched-chain amino acids metabolism to interferon signaling to sustain macrophage inflammation.Nature immunology · 2026Article
- Body weight predicts denosumab pharmacodynamic duration: a real-world longitudinal cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- PIDDosome deficiency impairs bone remodeling by increasing osteoclast ploidy and function.Cell death and differentiation · 2026Article
- Keeping bone resorption markers very low for 1 year after denosumab prevents bone loss at 2 years: the ReoLaus study.Archives of osteoporosis · 2026Article
- Impact of denosumab therapy on periapical healing following root canal treatment: a 10-year retrospective case-control study.BMC oral health · 2026Article
- Discontinuing Long-Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?Clinical pharmacology and therapeutics · 2026Review
- Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.Nature genetics · 2026Article
- A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast-Dependent Osteomimicry in Prostate Cancer Cells.Advanced healthcare materials · 2026Article
- Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment-Naive Patients Compared With Zoledronate.Clinical pharmacology and therapeutics · 2026Article
- Apoptotic bodies in bone homeostasis and skeletal disease: biology and therapeutic implications.Apoptosis : an international journal on programmed cell death · 2026Review
- Hijacking the bone niche: mechanistic insights into bone metastasis in breast cancer.Bone research · 2026Review
- Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.bioRxiv : the preprint server for biology · 2026Article
- Constructing advanced electrospun nanofiber/hydrogel composite scaffolds loading with nano hydroxyapatite and puerarin for promoting osseointegration and osteanagenesis in a rat cranial defect model.Materials today. Bio · 2026Article
- Transcriptome Analysis of Differentially Expressed Genes and Molecular Pathways Involved During Osteoclast Differentiation.Molecular biotechnology · 2026Article
163 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
47 authors at 11 institutions in 4 countries.
Michelle M McDonaldHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Weng Hua KhooHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Pei Ying NgBone Biology & Disease Laboratory, School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia.
Ya XiaoHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Jad ZamerliHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Peter ThatcherHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Wunna KyawImmunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Karrnan PathmanandavelImmunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Abigail K GrootveldImmunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Imogen MoranImmunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Danyal ButtImmunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Akira NguyenImmunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Alexander CorrHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Sean WarrenCancer, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Maté BiroEMBL Australia, Single Molecule Science Node, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Natalie C ButterfieldMolecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Siobhan E GuilfoyleMolecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Davide Komla-EbriMolecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Michael R G DackMolecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Hannah F DewhurstMolecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
John G LoganMolecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Yongxiao LiJohn Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Sindhu T MohantyHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Niall ByrneHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Rachael L TerryHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Marija K SimicHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Ryan ChaiHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Julian M W QuinnHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Scott E YoultenHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Jessica A PettittHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
David Abi-HannaHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Rohit JainImmune Imaging Program, Centenary Institute, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Wolfgang WeningerImmune Imaging Program, Centenary Institute, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Mischa LundbergThe University of Queensland Diamantina Institute, University of Queensland, Woolloongabba, QLD, Australia; Transformational Bioinformatics, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, Australia.
Shuting SunBiovinc, Pasadena, CA, USA.
Frank H EbetinoBiovinc, Pasadena, CA, USA.
Paul TimpsonCancer, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Woei Ming LeeJohn Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Paul A BaldockHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Michael J RogersHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia.
Robert BrinkSt. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Graham R WilliamsMolecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
J H Duncan BassettMolecular Endocrinology Laboratory, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
John P KempThe University of Queensland Diamantina Institute, University of Queensland, Woolloongabba, QLD, Australia; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Nathan J PavlosBone Biology & Disease Laboratory, School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia.
Peter I CroucherHealthy Ageing Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia. Electronic address: p.croucher@garvan.org.au.
Tri Giang PhanSt. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, Australia; Immunology Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia. Electronic address: t.phan@garvan.org.au.
Garvan Institute of Medical Research · AUImperial College London · GBSt Vincent's Clinic · AUUNSW Sydney · AUAustralian National University · AUBioVinc (United States) · USUniversity of Western Australia · AUCentenary Institute · AUCommonwealth Scientific and Industrial Research Organisation · AUMedical University of Vienna · ATUniversity of Queensland · AU
Funding
Wellcome Trust
Abstract
Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. Here, by intravital imaging, we reveal that RANKL-stimulated osteoclasts have an alternative cell fate in which they fission into daughter cells called osteomorphs. Inhibiting RANKL blocked this cellular recycling and resulted in osteomorph accumulation. Single-cell RNA sequencing showed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages and express a number of non-canonical osteoclast genes that are associated with structural and functional bone phenotypes when deleted in mice. Furthermore, genetic variation in human orthologs of osteomorph genes causes monogenic skeletal disorders and associates with bone mineral density, a polygenetic skeletal trait. Thus, osteoclasts recycle via osteomorphs, a cell type involved in the regulation of bone resorption that may be targeted for the treatment of skeletal diseases.
Indexed as
AnimalsApoptosisBone ResorptionCell FusionCells, CulturedHumansMacrophagesMiceOsteochondrodysplasiasOsteoclastsRANK LigandSignal TransductionRANK LigandTnfsf11 protein, mousecell fissioncellular recyclingdenosumabmacrophageosteoclastosteomorphosteoporosisosteoprotegerinRANKLskeletal dysplasia
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.