Evidence map›Paper›PMID 33635886›Full record

ArticlePloS one2021

A qualitative investigation of HIV treatment dispensing models and impacts on adherence among people living with HIV who use drugs.

Taylor Fleming, Alexandra B Collins, Geoff Bardwell, Al Fowler, Jade Boyd, M J Milloy, Will Small, Ryan McNeil

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Taylor FlemingBritish Columbia Centre on Substance Use, Vancouver, BC, Canada.
Alexandra B CollinsDepartment of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, United States of America.
Geoff BardwellBritish Columbia Centre on Substance Use, Vancouver, BC, Canada.
Al FowlerBritish Columbia Centre on Substance Use, Vancouver, BC, Canada.
Jade BoydBritish Columbia Centre on Substance Use, Vancouver, BC, Canada.
M J MilloyBritish Columbia Centre on Substance Use, Vancouver, BC, Canada.
Will SmallBritish Columbia Centre on Substance Use, Vancouver, BC, Canada.ORCID 0000-0001-6717-904X
Ryan McNeilBritish Columbia Centre on Substance Use, Vancouver, BC, Canada.ORCID 0000-0003-4452-0764
University of British Columbia · CABrown University · USBritish Columbia Centre on Substance Use · CAYale University · US

Funding

An ethno-epidemiological study to advance HIV prevention and treatment for PWUDR01DA043408 · NIDA · SIMON FRASER UNIVERSITY · PI MCNEIL, RYAN, SMALL, WILL · 2017 to 2021
$1.7M
CIHR CBF – 362965NIDA NIH HHS R01 DA043408
6 · The paper itself

Abstract

Antiretroviral therapy (ART) dispensing is strongly associated with treatment adherence. Among illicit drug-using populations, whom experience greater structural barriers to adherence, directly administered antiretroviral therapy (DAAT) is often regarded as a stronger predictor of optimal adherence over self-administered medications. In Vancouver, Canada, people living with HIV (PLHIV) who use drugs and live in low-income housing are a critical population for treatment support. This group is typically able to access two key DAAT models, daily delivery and daily pickup, in addition to ART self-administration. This ethno-epidemiological qualitative study explores how key dispensing models impact ART adherence among PLHIV who use drugs living in low-income housing, and how this is framed by structural vulnerability. Semi-structured interviews lasting 30-45 minutes were conducted between February and May 2018 with 31 PLHIV who use drugs recruited from an ongoing prospective cohort of PLHIV who use drugs. Interviews were audio-recorded, transcribed verbatim, and analyzed using QSR International's NVivo 12 software. Interviews focused on housing, drug use, and HIV management. Models that constrained agency were found to have negative impacts on adherence and quality of life. Treatment interruptions were framed by structural vulnerabilities (e.g., housing vulnerability) that impacted ability to maintain adherence under certain dispensing models, and led participants to consider other models. Participants using DAAT models which accounted for their structural vulnerabilities (e.g., mobility issues, housing instability), credited these models for their treatment adherence, but also acknowledged factors that constrained agency, and the negative impacts this could have on both adherence, and quality of life. Being able to integrate ART into an established routine is key to supporting ART adherence. ART models that account for the structural vulnerability of PLHIV who use drugs and live in low-income housing are necessary and housing-based supports could be critical, but the impacts of such models on agency must be considered to ensure optimal adherence.

Indexed as

Drug UsersMedication AdherenceAdultAnti-Retroviral AgentsCanadaFemaleHIV InfectionsHumansMaleMiddle AgedQualitative ResearchQuality of LifeSelf AdministrationAnti-Retroviral Agents

Identifiers

PMID33635886
PMCPMC7909635
OpenAlexW3133060278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.