ArticleeLife2021
Brain endothelial cell TRPA1 channels initiate neurovascular coupling.
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Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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95citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
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Who cites it
95 citing papers in PubMed, 117 citations in OpenAlex.
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- Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026Review
- Cerebral capillary computation.American journal of physiology. Cell physiology · 2026Review
- Ultrasonic repression of TRPA1-dependent astrocyte reactivity confers neuroprotection in models of Lewy body dementia.Translational neurodegeneration · 2026Article
- Skin capillary endothelial cells form a network of spatiotemporally conserved CabioRxiv : the preprint server for biology · 2026Article
- The Emerging Role of Endothelial Ion Channels in the Control of Human Microcirculation.International journal of molecular sciences · 2026Review
- Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model.The Journal of physiology · 2026Review
- Brain Capillary Ion Channels: Physiology and Channelopathies.Physiology (Bethesda, Md.) · 2026Review
- Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.Frontiers in cellular neuroscience · 2026Review
- A 3D-1D-0D multiscale model of the neuro-glial-vascular unit for synaptic and vascular dynamics in the dorsal vagal complex.Journal of mathematical biology · 2025Article
- Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025Review
- Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation and vascular fitness.bioRxiv : the preprint server for biology · 2025Article
- Mechanosensing of Shear Stress and Uterine Spiral Artery Remodeling by Invasive Trophoblasts in Early Pregnancy.International journal of molecular sciences · 2025Review
- Diversity of Brain Microvascular Endothelial Cell Functions: Physiology, Ischemia/Hypoxia, and Underlying Protection.Aging and disease · 2025Review
- Article
- Microtubule-Dependent CaJournal of the American Heart Association · 2025Article
- Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression.Cell & bioscience · 2025Review
- High-fat feeding has sex-dependent effects on the structure and biomechanical properties of cerebral parenchymal arterioles and cognitive function.American journal of physiology. Heart and circulatory physiology · 2025Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 2 countries.
Pratish ThakoreDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.ORCID 0000-0002-2086-5453
Michael G AlvaradoDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.ORCID 0000-0002-3489-9021
Sher AliDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.
Amreen MughalDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, United States.ORCID 0000-0002-0046-2286
Paulo W PiresDepartment of Physiology, College of Medicine, University of Arizona, Tucson, United States.ORCID 0000-0001-5972-4554
Evan YamasakiDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.
Harry At PritchardDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.
Brant E IsaksonDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States.
Cam Ha T TranDepartment of Physiology & Cell Biology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.
Scott EarleyDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.ORCID 0000-0001-9560-2941
University of Nevada, Reno · USUniversity of Arizona · USUniversity of Vermont · USUniversity of Virginia · US
Funding
Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A. · 2014 to 2023
$24.0MTransgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3MTRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5MTRP Channel-Dependent Regulation of Arterial Tone (Renewal)R01HL091905 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2009 to 2020
$5.1MPurinergic Regulation of Veinous Endothelial PermeabilityR01HL137112 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson, MICHAEL H. KOVAL · 2018 to 2026
$4.7MMechanisms of Functional Vascular Impairment In Genetic Models of Cerebral Small Vessel DiseaseRF1NS110044 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EARLEY, SCOTT, GOULD, DOUGLAS · 2018 to 2022
$3.3MRole of ANO1 Channels and Its Regulation by PIP2 in EC-Coupling in Pulmonary Artery MyocytesR01HL146054 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT, LEBLANC, NORMAND · 2019 to 2022
$2.0MSensory mechanisms in brain capillary endothelial cells that initiate functional hyperemiaR01HL139585 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.7MStructural Basis of Peripheral Coupling Sites Regulating Arterial Smooth Muscle Contractility (A1)R01HL137852 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.6MDevelopment and validation of novel models for cerebral small vessel disease and vascular cognitive impairmentR61NS115132 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, EARLEY, SCOTT · 2019 to 2020
$1.1MCerebral functional hyperemia responses induced by capillary NMDA receptors are disrupted by amyloid-beta accumulationK99HL140106 · NHLBI · UNIVERSITY OF NEVADA RENO · PI PIRES, PAULO W · 2018 to 2019
$165kNHLBI NIH HHS K99 HL140106NHLBI NIH HHS P01 HL120840NHLBI NIH HHS R01 HL091905NHLBI NIH HHS R01 HL137112NHLBI NIH HHS R01 HL137852NHLBI NIH HHS R01 HL139585NHLBI NIH HHS R01 HL146054NHLBI NIH HHS R35 HL155008NIGMS NIH HHS P20 GM130459NINDS NIH HHS R61 NS115132NINDS NIH HHS RF1 NS110044
Abstract
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagating retrograde signal that dilates upstream parenchymal arterioles to initiate functional hyperemia. We find that activation of TRPA1 in capillary beds and post-arteriole transitional segments with mural cell coverage initiates retrograde signals that dilate upstream arterioles. These signals exhibit a unique mode of biphasic propagation. Slow, short-range intercellular Ca
Indexed as
Cerebrovascular CirculationArteriolesBrainCapillariesEndothelial CellsNeurovascular CouplingTRPA1 Cation ChannelTRPA1 Cation ChannelTrpa1 protein, mouseconducted vasodilationmouseneuroscienceneurovascular couplingpanx1 channelspurinergic signalingTRPA1 channels
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