ArticleJournal of natural products2021
Exploring the Chemistry of Alkaloids from Malaysian
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Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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0cells of the map it votes in
48citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
What it found
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Who cites it
48 citing papers in PubMed, 72 citations in OpenAlex.
- Simultaneous quantification of seventeen kratom alkaloids and metabolites in human plasma and its application to clinical pharmacokinetic sample analysis.Pharmaceutical biology · 2026Article
- Spirooxindole Derivatives as Emerging Scaffolds in Drug Discovery: Synthetic Strategies, Structure-Activity Relationship, and Biological Activities.ChemMedChem · 2026Review
- Mixtures Biotransformation: Multilayer Molecular Networking of Kratom Liver Metabolites.Journal of natural products · 2026Article
- Environmental Influence on the Untargeted Foliar Metabolome of Naturally GrowingPlant-environment interactions (Hoboken, N.J.) · 2026Article
- UV-B and far-red light shape morphological and phytochemical responses in kratom.Frontiers in plant science · 2026Article
- Multifaceted modulation of human opioid receptors by kratom alkaloids: binding affinity, functional selectivity, and allosteric activity.Frontiers in pharmacology · 2026Article
- Observational real-world analysis of dose-dependent effects ofFrontiers in pharmacology · 2026Article
- Elevated 7-Hydroxymitragynine Levels Found in Products Misbranded as Kratom.Journal of AOAC International · 2026Article
- Evaluation of the unregulated online kratom market in two east-central European countries: test purchase and analysis of potential toxicological consequences.Harm reduction journal · 2025Article
- Four enzymes from button bush enable de novo biosynthesis of spirooxindole alkaloids in yeast.Biodesign research · 2025Article
- Mitragynine and 7-hydroxymitragynine: Bidirectional effects on breathing in rats.The Journal of pharmacology and experimental therapeutics · 2025Article
- In vitro skin permeation of mitragynine: Optimisation of antioxidants for enhanced drug stability and formulation performance.Drug delivery and translational research · 2025Article
- The acute adverse health effects of kratom: an evaluation of case reports.Frontiers in pharmacology · 2025Review
- Alkaloid biosynthesis in medicinal crop kratom (Frontiers in plant science · 2025Article
- The potential ofJournal of integrative bioinformatics · 2024Article
- Kratom: A Narrative Review of the Possible Clinical Uses and Dangers of This Opioid-Like Plant.Cureus · 2024Review
- The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic αEuropean journal of pharmacology · 2024Article
- Multimodal Image Fusion Workflow Incorporating MALDI Imaging Mass Spectrometry and Microscopy for the Study of Small Pharmaceutical Compounds.Analytical chemistry · 2024Article
- Article
- An In Vitro Examination of Whether Kratom Extracts Enhance the Cytotoxicity of Low-Dose Doxorubicin against A549 Human Lung Cancer Cells.Molecules (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Nelson Jeng-Yeou ChearCentre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
Francisco LeónDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-5064-2381
Abhisheak SharmaDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0003-0553-4039
Siva Rama Raju KanumuriDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Grant ZwolinskiDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Khalil A AbboudDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Darshan SinghCentre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
Luis F RestrepoDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Avi PatelDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Takato HiranitaDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Surash RamanathanCentre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
Aidan J HampsonDivision of Therapeutics and Medical Consequences, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, United States.
Lance R McMahonDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Christopher R McCurdyDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-8695-2915
University of Florida · USUniversiti Sains Malaysia · MYNational Institutes of Health · US
Funding
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MOpioid use disorders: UF Pharmacy medications discovery and developmentUG3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2020
$3.6MKratom alkaloids: in vitro and in vivo pharmacological mechanismsR01DA047855 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2023
$3.6MNCATS NIH HHS UL1 TR001427NIDA NIH HHS R01 DA047855NIDA NIH HHS UG3 DA048353
Abstract
Ten indole and oxindole alkaloids (
Indexed as
AnalgesicsAnimalsFemaleHumansIndolesMalaysiaMaleMitragynaMolecular StructureOxindolesPlant LeavesRatsRats, Sprague-DawleyReceptors, Opioid, muSecologanin Tryptamine AlkaloidsSpiro CompoundsAnalgesicscorynoxineIndolesmitragynineOxindolesReceptors, Opioid, muSecologanin Tryptamine AlkaloidsSpiro Compounds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.