ArticleNano letters2021
Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors.
Article in Nano letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
91 citing papers in PubMed, 222 citations in OpenAlex.
- Nonenzymatic Detection of SARS-CoV‑2 RNA Using DNA Nanoswitches.ACS nano medicine · 2026Article
- Quantifying Population Reversibility of Sensor Performance in Multi-Cycle Single-Sensor Recovery Assay.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Aptamer-Functionalized SWCNT Optical Sensors for Selective and Robust Dopamine Detection in Physiological Media.ACS applied nano materials · 2026Article
- Rational Design of Optical Single-Walled Carbon Nanotube-Based Nanosensors with Biological Recognition Elements.Advanced sensor research · 2026Article
- Selective and robust dopamine detection is enabled by aptamer-SWCNT optical sensors in physiological media.bioRxiv : the preprint server for biology · 2026Article
- Review
- Machine Learning Prediction of Analyte-Induced Fluorescence Perturbations in DNA-Functionalized Carbon Nanotubes.Nano letters · 2026Article
- Nanotechnology in COVID-19 prevention, diagnosis, and treatment: a comprehensive review.Discover nano · 2025Review
- Single-walled carbon nanotubes sensors: Preparation and bio-application advances.Pharmaceutical science advances · 2025Review
- From Aerosol to Signal: Advances in Biosensor Technologies for Airborne Biothreat Detection.Biosensors · 2025Review
- Innovation landscape in nanobiosensors for COVID-19 detection and future implications for a resilient Global Health Security.3 Biotech · 2025Review
- Metal-Ion Optical Fingerprinting Sensor Selection via an Analyte Classification and Feature Selection Algorithm.Analytical chemistry · 2025Article
- Understanding DNA-encoded carbon nanotube sorting and sensing via sub-nm-resolution structural determination.Science advances · 2025Article
- Emerging Trends of Gold Nanostructures for Point-of-Care Biosensor-Based Detection of COVID-19.Molecular biotechnology · 2025Review
- Effect of Polyelectrolytes on the Photoluminescence of Single-Walled Carbon Nanotubes-Experimental and Simulation Studies.ACS omega · 2025Article
- Article
- Dual Infrared 2-Photon Microscopy Achieves Minimal Background Deep Tissue Imaging in Brain and Plant Tissues.Advanced functional materials · 2024Article
- Ratiometric Normalization of Near-Infrared Fluorescence in Defect-Engineered Single-Walled Carbon Nanotubes for Cholesterol Detection.The journal of physical chemistry letters · 2024Article
- FEM simulation of SARS-CoV-2 sensing in single-layer graphene-based bionanosensors.Journal of molecular modeling · 2024Article
- Covalent Attachment of Horseradish Peroxidase to Single-Walled Carbon Nanotubes for Hydrogen Peroxide Detection.Advanced functional materials · 2024Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
To effectively track and eliminate COVID-19, it is critical to develop tools for rapid and accessible diagnosis of actively infected individuals. Here, we introduce a single-walled carbon nanotube (SWCNT)-based optical sensing approach toward this end. We construct a nanosensor based on SWCNTs noncovalently functionalized with ACE2, a host protein with high binding affinity for the SARS-CoV-2 spike protein. The presence of the SARS-CoV-2 spike protein elicits a robust, 2-fold nanosensor fluorescence increase within 90 min of spike protein exposure. We characterize the nanosensor stability and sensing mechanism and passivate the nanosensor to preserve sensing response in saliva and viral transport medium. We further demonstrate that these ACE2-SWCNT nanosensors retain sensing capacity in a surface-immobilized format, exhibiting a 73% fluorescence turn-on response within 5 s of exposure to 35 mg/L SARS-CoV-2 virus-like particles. Our data demonstrate that ACE2-SWCNT nanosensors can be developed into an optical tool for rapid SARS-CoV-2 detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.