Evidence map›Paper›PMID 33635423›Full record

ArticleJournal of autism and developmental disorders2022

Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism.

Simge Aykan, Meghan H Puglia, Canan Kalaycıoğlu, Kevin A Pelphrey, Timur Tuncalı, Erhan Nalçacı

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Article in Journal of autism and developmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Simge AykanDepartment of Physiology, Ankara University School of Medicine, Ankara, Turkey. saykan@ankara.edu.tr.ORCID http://orcid.org/0000-0002-0156-2860
Meghan H PugliaDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.
Canan KalaycıoğluDepartment of Physiology, Ankara University School of Medicine, Ankara, Turkey.
Kevin A PelphreyDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.
Timur TuncalıDepartment of Medical Genetics, Ankara University School of Medicine, Ankara, Turkey.
Erhan NalçacıDepartment of Physiology, Ankara University School of Medicine, Ankara, Turkey.
Ankara University · TRUniversity of Virginia · US

Funding

Ankara University Scientific Research Projects Funds I3-L333-033
6 · The paper itself

Abstract

Our aim was to use theta coherence as a quantitative trait to investigate the relation of the polymorphisms in NKCC1 (rs3087889) and KCC2 (rs9074) channel protein genes to autistic traits (AQ) in neurotypicals. Coherence values for candidate connection regions were calculated from eyes-closed resting EEGs in two independent groups. Hypersynchrony within the right anterior region was related to AQ in both groups (p < 0.05), and variability in this hypersynchrony was related to the rs9074 polymorphism in the total group (p < 0.05). In conclusion, theta hypersynchrony within the right anterior region during eyes-closed rest can be considered a quantitative measure for autistic traits. Replicating our findings in two independent populations with different backgrounds strengthens the validity of the current study.

Indexed as

Autism Spectrum DisorderAutistic DisorderSymportersElectroencephalographyHumansK Cl- CotransportersSolute Carrier Family 12, Member 2K Cl- CotransportersSLC12A2 protein, humanSLC12A5 protein, humanSolute Carrier Family 12, Member 2SymportersAutistic traitsCoherenceExcitation/inhibition imbalanceKCC2Quantitative traitsTheta oscillations

Identifiers

PMID33635423
OpenAlexW3132088955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.