Evidence map›Paper›PMID 33635390›Full record

ArticleJournal of neurology2021

Multifocal neutrophilic meningoencephalitis: a novel disorder responsive to anakinra.

Joseph R Berger, Clyde Markowitz, Peter A Merkel, Rachel A Kolster, Zissimos Mourelatos

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joseph R BergerDepartment of Neurology, Perelman School of Medicine, Perelman Center for Advanced Medicine, University of Pennsylvania, 3400 Convention Avenue, Philadelphia, PA, 19104, USA. joseph.berger@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-1540-496X
Clyde MarkowitzDepartment of Neurology, Perelman School of Medicine, Perelman Center for Advanced Medicine, University of Pennsylvania, 3400 Convention Avenue, Philadelphia, PA, 19104, USA.
Peter A MerkelDivision of Rheumatology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Rachel A KolsterDivision of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Zissimos MourelatosDivision of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
University of Pennsylvania · US

Funding

Training in Alzheimer’s and Age-Related Neurodegenerative DiseasesT32AG000255 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN, VIRGINIA M LEE · 1997 to 2026
$12.5M
NIA NIH HHS T32 AG000255
6 · The paper itself

Abstract

We report a 57-year-old man with recurrent meningoencephalitis resulting in bouts of altered consciousness, encephalopathy, tremors, focal seizures, and paraparesis. The neurological manifestations were accompanied by fever and leukocytosis in the absence of other systemic manifestations. MRI abnormalities of the brain, brainstem, spinal cord and meninges and CSF pleocytosis and elevated protein were observed. Exhaustive studies failed to reveal an etiology. Brain biopsy revealed nodules of neutrophils and macrophages, but no vasculitis. The lesions were not vasocentric as would be expected with neuro-Behcet's disease and neuro-Sweet's disease. The disorder was responsive to high-dose corticosteroid therapy and, ultimately, to anakinra, an IL-1α and IL-1β receptor antagonist.

Indexed as

Behcet SyndromeMeningoencephalitisSweet SyndromeHumansInterleukin 1 Receptor Antagonist ProteinMagnetic Resonance ImagingMaleMiddle AgedInterleukin 1 Receptor Antagonist ProteinAnakinraCNS inflammationMeningoencephalitisNeutrophils

Identifiers

PMID33635390
PMCPMC9394448
OpenAlexW3131156050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.