ArticleIntensive care medicine2021
Expanding controlled donation after the circulatory determination of death: statement from an international collaborative.
Article in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Ethical tensions and professional attitudes toward circulatory death organ donation in the ICU: a systematic review.Intensive care medicine · 2025Pooled it
- Pooled it
- Education and Ethical Guidance for Organ Donation at the End-of-Life: An Ethical Guidance Statement from the Neurocritical Care Society.Neurocritical care · 2026Review
- [Controlled Donation after Circulatory determination of Death (cDCD) : A position paper by the DCD working group of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI)].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- How Long Is the Brain Perfusable After Global Ischemia? A Systematic Review.Brain sciences · 2026Review
- Brain-Dead Organ Donation in Neurosurgical Care: Roles of Neurosurgeons and Collaboration With the Korea Organ Donation Agency (KODA).Korean journal of neurotrauma · 2026Review
- ECMO for patients needing surgery.Intensive care medicine · 2026Article
- Midazolam prescription as a trigger for potential deceased donor identification outside the ICU: a prospective feasibility study.BMC palliative care · 2026Article
- Organ donation after ECPR: ethical challenges and clinical implications.Critical care (London, England) · 2026Review
- Association of reduced physician requirements with brain death confirmation pathway duration and organ donation outcomes in the ICU: a retrospective cohort study.BMC anesthesiology · 2026Article
- Factors that create trust in the donation after circulatory death process among surgical personnel: a qualitative descriptive study.BMC health services research · 2026Article
- Recommendations in Extracorporeal Cardiopulmonary Resuscitation Post Resuscitation Care Via An International, Modified Delphi Approach.Journal of the American Heart Association · 2026Review
- Intensive care staff: the gatekeepers to donation after circulatory death.Intensive care medicine · 2026Article
- ECMO-Assisted In-Situ Normothermic Perfusion for Donation After Circulatory Determination of Death Kidney Transplantation: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Establishing standards for controlled donation after circulatory determination of death in adults: the Bucharest international European Society for Organ Transplantation consensus.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Seeking global agreement on controlled donation after circulatory determination of death: methodology and definitions of the Bucharest international European Society for Organ Transplantation (ESOT) consensus.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Potential for donation after circulatory death in Germany: a multicenter retrospective study at seven university hospitals.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Relatives' experiences of end-of-life care and organ donation after controlled circulatory death: a national prospective multicenter study.Critical care (London, England) · 2025Article
- Why is organ transplantation from cardiac death donors necessary in Japan? An important strategy for heart transplantation in severe donor shortage.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Ante-mortem interventions for deceased donation: legal barriers and uncertainty in Australia's decision-making frameworks.The Medical journal of Australia · 2025Article
Corrections and comments
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- Erratum issued
Authors and funding
23 authors at 20 institutions in 7 countries.
Funding
Abstract
A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that further treatment will not enable a patient to survive or will not produce a functional outcome with acceptable quality of life that the patient and the treating team regard as beneficial. Although many hospitalized patients die under such circumstances, controlled donation after the circulatory determination of death (cDCDD) programs have been developed only in a reduced number of countries. This International Collaborative Statement aims at expanding cDCDD in the world to help countries progress towards self-sufficiency in transplantation and offer more patients the opportunity of organ donation. The Statement addresses three fundamental aspects of the cDCDD pathway. First, it describes the process of determining a prognosis that justifies the WLST, a decision that should be prior to and independent of any consideration of organ donation and in which transplant professionals must not participate. Second, the Statement establishes the permanent cessation of circulation to the brain as the standard to determine death by circulatory criteria. Death may be declared after an elapsed observation period of 5 min without circulation to the brain, which confirms that the absence of circulation to the brain is permanent. Finally, the Statement highlights the value of perfusion repair for increasing the success of cDCDD organ transplantation. cDCDD protocols may utilize either in situ or ex situ perfusion consistent with the practice of each country. Methods to accomplish the in situ normothermic reperfusion of organs must preclude the restoration of brain perfusion to not invalidate the determination of death.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.