Evidence map›Paper›PMID 33635272›Full record

ArticleeLife2021

DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome.

Simona Hankeova, Jakub Salplachta, Tomas Zikmund, Michaela Kavkova, Noémi Van Hul, Adam Brinek, Veronika Smekalova, Jakub Laznovsky, Feven Dawit, Josef Jaros and 8 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Simona Hankeova *Department of Biosciences and Nutrition, Karolinska Institutet, Solna, Sweden.ORCID 0000-0002-7797-3818
Jakub Salplachta *CEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.ORCID 0000-0002-0149-7843
Tomas Zikmund *CEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Michaela Kavkova *CEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Noémi Van Hul *Department of Biosciences and Nutrition, Karolinska Institutet, Solna, Sweden.ORCID 0000-0003-1410-8808
Adam BrinekCEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Veronika SmekalovaCEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Jakub LaznovskyCEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Feven DawitDepartment of Pediatrics, Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Solna, Sweden.
Josef JarosDepartment of Histology and Embryology, Masaryk University, Brno, Czech Republic.
Vítězslav BryjaDepartment of Experimental Biology, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-9136-5085
Urban LendahlDepartment of Cell and Molecular Biology, Karolinska Institutet, Solna, Sweden.
Ewa EllisDepartment of Pediatrics, Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Solna, Sweden.ORCID 0000-0002-3057-5337
Antal NemethDepartment of Laboratory Medicine, Karolinska Institutet, Solna, Sweden.
Björn FischlerDepartment of Pediatrics, Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Solna, Sweden.
Edouard HannezoInstitute of Science and Technology, Klosterneuburg, Austria.ORCID 0000-0001-6005-1561
Jozef KaiserCEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Emma Rachel AnderssonDepartment of Biosciences and Nutrition, Karolinska Institutet, Solna, Sweden.ORCID 0000-0002-8608-625X
Central European Institute of Technology · CZKarolinska Institutet · SEKarolinska University Hospital · SEMasaryk University · CZInstitute of Science and Technology Austria · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digitalize, and segment the architecture of two tubular systems in 3D:

Indexed as

Alagille SyndromeAnimalsBile DuctsDisease Models, AnimalMiceMice, TransgenicX-Ray MicrotomographyAlagille syndromecholangiopathyhumanMicroCTmousephysics of living systemsregenerative medicineresinstem cellsvasculature

Identifiers

PMID33635272
PMCPMC7909953
OpenAlexW3133204495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.