ArticleJournal of the American Chemical Society2021
Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Enantioselective Synthesis of a New Class of Stable and Functionalized Cyclopentadienes via CuH-Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis of Sterically Congested Carbonyl Compounds via anJournal of the American Chemical Society · 2025Article
- Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents.Molecules (Basel, Switzerland) · 2025Review
- Rapid assembly of enantioenriched α-arylated ketones via Ni-catalyzed asymmetric cross-hydrocarbonylation enabled by alkene sorting.Nature communications · 2025Article
- Copper-catalysed dynamic kinetic asymmetric C-O cross-coupling to access chiral aryl oxime ethers and diaryl ethers.Nature communications · 2025Article
- Enantioselective Synthesis of α-Aryl Ketones by a Cobalt-Catalyzed Semipinacol Rearrangement.Angewandte Chemie (International ed. in English) · 2025Article
- Ligand-Metal Cooperation Enables Net Ring-Opening C-C Activation / Difunctionalization of Cyclopropyl Ketones.ACS catalysis · 2023Article
- Insights into Single-Electron-Transfer Processes in Frustrated Lewis Pair Chemistry and Related Donor-Acceptor Systems in Main Group Chemistry.Chemical reviews · 2023Review
- Catalytic asymmetric defluorinative allylation of silyl enol ethers.Chemical science · 2023Article
- Enantioselective synthesis of α,α-diarylketones by sequential visible light photoactivation and phosphoric acid catalysis.Science advances · 2023Article
- Boosting the Enantioselectivity of Conjugate Borylation of α,β-Disubstituted Cyclobutenones with Monooxides of Chiral CChemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Synthesis of Cyclohexanones by a Tandem Photocatalyzed Annulation.Journal of the American Chemical Society · 2022Article
- Stereoselective Synthesis of Cyclobutanes by Contraction of Pyrrolidines.Journal of the American Chemical Society · 2021Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides is described. This allows the arylation of silyl enol ethers to access enolizable α-arylated ketones in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation analysis. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides.
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