Evidence map›Paper›PMID 33635063›Full record

ArticleACS sensors2021

Point-of-Care Monitoring of Colitis Using Intestinal Alkaline Phosphatase in Inflammatory Bowel Disease.

Xiaolin Sheng, Dandan Liu, Sujani K Gamage, Ying Luo, Emilie Viennois, Didier Merlin, Suri S Iyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaolin ShengDepartment of Chemistry, Georgia State University 788 Petit Science Center, Atlanta, Georgia 30302, United States.
Dandan LiuDepartment of Chemistry, Georgia State University 788 Petit Science Center, Atlanta, Georgia 30302, United States.
Sujani K GamageDepartment of Chemistry, Georgia State University 788 Petit Science Center, Atlanta, Georgia 30302, United States.
Ying LuoDepartment of Chemistry, Georgia State University 788 Petit Science Center, Atlanta, Georgia 30302, United States.
Emilie ViennoisInstitute for Biomedical Sciences, Georgia State University, 790 Petit Science Center, Atlanta, Georgia 30302, United States.
Didier MerlinInstitute for Biomedical Sciences, Georgia State University, 790 Petit Science Center, Atlanta, Georgia 30302, United States.
Suri S IyerDepartment of Chemistry, Georgia State University 788 Petit Science Center, Atlanta, Georgia 30302, United States.ORCID 0000-0002-6196-006X
Georgia State University · US

Funding

Point of care diagnostics for home monitoring of Inflammatory Bowel DiseaseR21EB025049 · NIBIB · GEORGIA STATE UNIVERSITY · PI IYER, SURI SARANATHAN · 2017 to 2018
$417k
BLR&D Research Career Scientist Award ApplicationIK6BX004476 · VA · VETERANS HEALTH ADMINISTRATION · PI MERLIN, DIDIER · 2019 to 2025
–
BLRD VA IK6 BX004476NIBIB NIH HHS R21 EB025049
6 · The paper itself

Abstract

Intestinal Alkaline Phosphatase (IAP) was investigated as a potential biomarker to monitor colitis in a mouse model of Inflammatory Bowel Disease (IBD). We developed a Point-Of-Care (POC) assay to detect IAP with a glucose meter in 15 min. We synthesized a paracetamol-bearing compound specifically cleaved by IAP to release paracetamol, which can be detected with a personal glucometer. Interleukin 10 deficient (IL 10-/-) mouse model samples were used to compare the IAP level in mice with mild or severe colitis. The results showed that fecal IAP level was significantly lower in each mouse sample with severe colitis than with mild colitis. Mice treated with anti-Tumor Necrosis Factor-alpha (anti-TNF-α) to decrease inflammation exhibited a much higher level of IAP than those without treatment (IAP levels from anti-TNF-α treated vs nontreated = 2.80 U vs 0.11 U,

Indexed as

ColitisInflammatory Bowel DiseasesAlkaline PhosphataseAnimalsIntestinal MucosaMicePoint-of-Care SystemsTumor Necrosis Factor-alphaAlkaline PhosphataseTumor Necrosis Factor-alphaglucose meterinflammatory bowel diseaseInterleukin 10 deficient (IL-10−/−) miceintestinal alkaline phosphatasepoint-of-care

Identifiers

PMID33635063
PMCPMC8628551
OpenAlexW3133300495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.