Evidence map›Paper›PMID 33634803›Full record

ArticleChemical communications (Cambridge, England)2021

Tetra-arylborate lipophilic anions as targeting groups.

Kishore K Gaddale Devanna, Justyna M Gawel, Tracy A Prime, Filip Cvetko, Cristiane Benincá, Stuart T Caldwell, Alexander Negoda, Andrew Harrison, Andrew M James, Evgeny V Pavlov and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Kishore K Gaddale DevannaSchool of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK. Richard.Hartley@glasgow.ac.uk.
Justyna M Gawel
Tracy A Prime
Filip Cvetko
Cristiane Benincá
Stuart T Caldwell
Alexander Negoda
Andrew Harrison
Andrew M James
Evgeny V Pavlov
Michael P Murphy
Richard C Hartley
University of Cambridge · GBGlasgow Life · GBDalhousie University · CANew York University · US

Funding

Medical Research Council MC_U105663142Wellcome Trust 110158/Z/15/Z
6 · The paper itself

Abstract

Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.

Indexed as

Hydrophobic and Hydrophilic InteractionsBiological TransportBoratesCell Line, TumorHumansHydrogen-Ion ConcentrationLysosomesModels, MolecularMolecular ConformationBorates

Identifiers

PMID33634803
PMCPMC8062962
OpenAlexW3130915632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.