Evidence map›Paper›PMID 33634707›Full record

Trial reportThe Journal of urology2021

A Phase 2/3 Prospective Multicenter Study of the Diagnostic Accuracy of Prostate Specific Membrane Antigen PET/CT with

Kenneth J Pienta, Michael A Gorin, Steven P Rowe, Peter R Carroll, Frédéric Pouliot, Stephan Probst, Lawrence Saperstein, Mark A Preston, Ajjai S Alva, Akash Patnaik and 7 more

2 registry-linked trialsOpen access · hybridAbstract readClinical Trial, Phase IIClinical Trial, Phase IIIMulticenter Study
In one paragraph

Trial report in The Journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 205 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 5 pooled it
38.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05936658 phase3active not recruitingnot on this mapstarted 2023, after this paper: background citation

A Multi-center, Open-label, Single Arm Phase III Clinical Trial for the Diagnostic Efficacy Assessment and Safety Evaluation by [18F]Florastamin PET/CT Imaging Examination in Patients With Suspected Recurrent or Metastatic Prostate Cancer

TypeinterventionalSponsorFutureChemRan2023 to 2025Enrolled138ConditionsHigh Risk Prostate CarcinomaArms[F-18]Florastamin
NCT07635524 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Two Center Phase 2 Trial of 61Cu-noDAGa-PSMA I&T (61Cu-NU101) for Patients With Prostate Cancer

TypeinterventionalSponsorHoag Memorial Hospital PresbyterianRan2026 to 2028Enrolled34ConditionsProstate CancerArmsCu-NU101
3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 5 syntheses or guidelines pooled it, 354 citations in OpenAlex.

  1. Recommendations from the Galician Oncological Society and the Galician Society of Nuclear Medicine for the use ofClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Guideline
  2. Pooled it
  3. Pooled it
  4. Utility of PSMA PET/CT in Staging and Restaging of Renal Cell Carcinoma: A Systematic Review and Metaanalysis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Pooled it
  5. Guideline
  6. Trial
  7. Trial
  8. The German Cancer Consortium (DKTK) multi-center prospective phase 1/2European journal of nuclear medicine and molecular imaging · 2026
    Trial
  9. Trial
  10. Imaging Efficacy of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  11. Trial
  12. Trial
  13. AnCurrent radiopharmaceuticals · 2024
    Trial
  14. [European journal of nuclear medicine and molecular imaging · 2023
    Trial
  15. Radiology · 2022
    Trial
  16. Trial
  17. Review
  18. Review
  19. Review
  20. Article

145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 2 countries.

Kenneth J PientaThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Michael A GorinThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Steven P RoweThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Peter R CarrollUniversity of California San Francisco, San Francisco, California.
Frédéric PouliotCHU de Quebec and Laval University, Quebec City, Quebec.
Stephan ProbstJewish General Hospital, Montreal, Quebec.
Lawrence SapersteinYale School of Medicine, New Haven, Connecticut.
Mark A PrestonBrigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts.
Ajjai S AlvaUniversity of Michigan, Ann Arbor, Michigan.
Akash PatnaikSection of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois.
Jeremy C DurackMemorial Sloan Kettering Cancer Center, New York, New York.
Nancy StamblerProgenics Pharmaceuticals, Inc., New York, New York.
Tess LinProgenics Pharmaceuticals, Inc., New York, New York.
Jessica JensenProgenics Pharmaceuticals, Inc., New York, New York.
Vivien WongProgenics Pharmaceuticals, Inc., New York, New York.
Barry A SiegelMallinckrodt Institute of Radiology and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Michael J MorrisMemorial Sloan Kettering Cancer Center, New York, New York.
Progenics Pharmaceuticals (United States) · USJohns Hopkins Medicine · USAlvin J. Siteman Cancer CenterCornell University · USDana-Farber Brigham Cancer Center · USJewish General Hospital · CAJohns Hopkins University · USMemorial Sloan Kettering Cancer Center · USUniversité Laval · CAUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Michigan–Ann Arbor · USYale University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2016 to 2020
$9.9M
PURCHASE OF A SIEMENS NEXT GENERATION PET/CTS10OD025214 · OD · WASHINGTON UNIVERSITY · PI WOODARD, PAMELA K · 2018 to 2018
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS U54 CA210173NIH HHS S10 OD025214
6 · The paper itself

Abstract

purposeProstate specific membrane antigen-targeted positron emission tomography/computerized tomography has the potential to improve the detection and localization of prostate cancer. OSPREY was a prospective trial designed to determine the diagnostic performance of MATERIALS AND

methodsTwo patient populations underwent

resultsA total of 385 patients were enrolled. In cohort A (252 evaluable patients),

conclusionsThe primary end point for specificity was met while the primary end point for sensitivity was not. The high positive predictive value observed in both cohorts indicates that

Indexed as

Positron Emission Tomography Computed TomographyProstate-Specific AntigenAgedAged, 80 and overHumansLysineMaleMiddle AgedNeoplasm MetastasisProspective StudiesProstatic NeoplasmsReproducibility of ResultsUrea2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acidLysineProstate-Specific AntigenUreamolecular imagingneoplasm metastasisneoplasm stagingprostatic neoplasms

Identifiers

PMID33634707
PMCPMC8556578
OpenAlexW3132398728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.