Evidence map›Paper›PMID 33634702›Full record

ArticleJournal of the American Heart Association2021

Cholesterol Efflux and Collateral Circulation in Chronic Total Coronary Occlusion: Effect-Circ Study.

Seonhwa Lee, Jung Mi Park, Soo-Jin Ann, Moonjong Kang, Eun Jeong Cheon, Dan Bi An, Yu Ri Choi, Chan Joo Lee, Jaewon Oh, Sungha Park and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Seonhwa LeeDivision of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea.
Jung Mi ParkDepartment of Biostatistics and Computing Graduate School Yonsei University Seoul Korea.
Soo-Jin AnnIntegrative Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of MedicineYonsei University Health System Seoul Korea.
Moonjong KangDepartment of Biostatistics and Computing Graduate School Yonsei University Seoul Korea.
Eun Jeong CheonIntegrative Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of MedicineYonsei University Health System Seoul Korea.
Dan Bi AnGraduate Program of Science for Aging Graduate School Yonsei University Seoul Korea.
Yu Ri ChoiGraduate Program of Science for Aging Graduate School Yonsei University Seoul Korea.
Chan Joo LeeDivision of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea.
Jaewon OhDivision of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea.
Sungha ParkDivision of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea.
Seok-Min KangDivision of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea.
Sang-Hak LeeDivision of Cardiology Department of Internal Medicine Severance HospitalYonsei University College of MedicineYonsei University Health System Seoul Korea.
Severance Hospital · KRYonsei University · KRYonsei University Health System · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The mechanism through which high-density lipoprotein (HDL) induces cardioprotection is not completely understood. We evaluated the correlation between cholesterol efflux capacity (CEC), a functional parameter of HDL, and coronary collateral circulation (CCC). We additionally investigated whether A1BP (apoA1-binding protein) concentration correlates with CEC and CCC. Methods and Results In this case-control study, clinical and angiographic data were collected from 226 patients (mean age, 58 years; male, 72%) with chronic total coronary occlusion. CEC was assessed using a radioisotope and J774 cells, and human A1BP concentration was measured using enzyme-linked immunosorbent assay. Differences between the good and poor CCC groups were compared, and associations between CEC, A1BP, and other variables were evaluated. Predictors of CCC were identified by multivariable logistic regression analysis. The CEC was higher in the good than in the poor CCC group (22.0±4.6% versus 20.2±4.7%;

Indexed as

AgedBiological TransportBiomarkersCholesterolChronic DiseaseCollateral CirculationCoronary AngiographyCoronary CirculationCoronary OcclusionCoronary VesselsEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHumansMaleMiddle AgedBiomarkersCholesterolapolipoprotein A‐1coronary artery diseaselipoproteinsmacrophages

Identifiers

PMID33634702
PMCPMC8174259
OpenAlexW3132028280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.