Evidence map›Paper›PMID 33634624›Full record

ArticleJournal of breast cancer2021

Palbociclib Plus Fulvestrant in Korean Patients from PALOMA-3 With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer.

Jee Hyun Kim, Seock Ah Im, Sung Hoon Sim, Eustratios Bananis, Xin Huang, Hyun Seon Kim, Sung Bae Kim

Open access · goldAbstract read
In one paragraph

Article in Journal of breast cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Jee Hyun KimDivision of Hematology & Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1336-3620
Seock Ah ImDivision of Hematology & Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. moisa@snu.ac.kr.ORCID https://orcid.org/0000-0002-5396-6533
Sung Hoon SimDepartment of Internal Medicine, National Cancer Center Korea, Goyang, Korea.ORCID https://orcid.org/0000-0002-1503-1075
Eustratios BananisPfizer Inc., New York, USA.ORCID https://orcid.org/0000-0001-6553-7114
Xin HuangPfizer Inc., San Diego, USA.ORCID https://orcid.org/0000-0003-3285-365X
Hyun Seon KimPfizer Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-4844-5175
Sung Bae KimDepartment of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5588-8332
Pfizer (United States) · USSeoul National University Hospital · KRNational Cancer Center · KRPfizer (South Korea) · KRUlsan College · KR

Funding

Pfizer NCT01942135
6 · The paper itself

Abstract

In the PALOMA-3 trial, the median progression-free survival (PFS) was longer among patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) treated with palbociclib plus fulvestrant than those treated with placebo plus fulvestrant. This subgroup analysis examined the efficacy and safety of palbociclib among Korean patients enrolled in PALOMA-3 (n = 43 [palbociclib group, n = 24; placebo group, n = 19]). In both groups, > 40% of patients were pre/perimenopausal at enrollment. The median PFS was significantly prolonged with palbociclib vs. placebo (12.3 [95% confidence interval (CI), 9.1-not estimable] vs. 5.4 months [95% CI, 1.9-9.2]; hazard ratio, 0.40 [95% CI, 0.19-0.83]; one-sided

Indexed as

Breast neoplasmsFulvestrantKoreaPalbociclib, Progression-free survival

Identifiers

PMID33634624
PMCPMC7920865
OpenAlexW3132367923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.