ArticleNMR in biomedicine2021
Measurement of cellular-interstitial water exchange time in tumors based on diffusion-time-dependent diffusional kurtosis imaging.
Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 42 citations in OpenAlex.
- MR Virtual Cytometry for Zone-specific Prostate Cancer Characterization with Histologic and Molecular Validation.Radiology. Imaging cancer · 2026Article
- Time-dependent diffusion MRI differentiates atypical from conventional uterine leiomyomas: A preliminary study.European journal of radiology open · 2026Article
- Complementary Sensitivity of Fixed-Time and Fixed-Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating-Gradient Diffusion MRI With Ultra-Strong Gradients.Magnetic resonance in medicine · 2026Article
- Monte Carlo Assessment of Accuracy for Mean Kärger Model Water Exchange Rate Estimates From Diffusional Kurtosis Time Dependence.NMR in biomedicine · 2026Article
- Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.Magnetic resonance in medicine · 2025Article
- Correcting pulse duration effects in the diffusional kurtosis of the multi-compartment Kärger model.Magnetic resonance in medicine · 2025Article
- Evaluating a Cellular Microstructure Model Within Apoptotic Cell Death via Diffusion Magnetic Resonance and Long Diffusion Times.NMR in biomedicine · 2025Article
- Comprehensive characterization of tumor therapeutic response via simultaneous mapping of cell size, density, and transcytolemmal water exchange.Magnetic resonance imaging · 2025Article
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging.Magnetic resonance in medicine · 2025Review
- Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from transient kurtosis.Scientific reports · 2025Article
- Revealing membrane integrity and cell size from diffusion kurtosis time dependence.Magnetic resonance in medicine · 2025Article
- In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI.Science advances · 2024Article
- Diffusional kurtosis time dependence and the water exchange rate for the multi-compartment Kärger model.Magnetic resonance in medicine · 2024Article
- Mean Kärger Model Water Exchange Rate in Brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence.Imaging neuroscience (Cambridge, Mass.) · 2024Article
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- Evaluation of cellular water exchange in a mouse glioma model using dynamic contrast-enhanced MRI with two flip angles.Scientific reports · 2023Article
- Time-dependent diffusivity and kurtosis in phantoms and patients with head and neck cancer.Magnetic resonance in medicine · 2023Article
- Preliminary study on intravoxel incoherent motion imaging and diffusion kurtosis imaging based on magnetic resonance imaging of normal kidneys in children.Translational pediatrics · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo assess the feasibility of using diffusion-time-dependent diffusional kurtosis imaging (tDKI) to measure cellular-interstitial water exchange time (τ
methodsPreclinical tDKI studies at 7 T were performed with the GL261 glioma model and the 4T1 mammary tumor model injected into the mouse brain. Clinical studies were performed at 3 T with women who had biopsy-proven invasive ductal carcinoma. tDKI measurement was conducted using a diffusion-weighted STEAM pulse sequence with multiple diffusion times (20-800 ms) at a fixed echo time, while keeping the b-values the same (0-3000 s/mm
resultsBoth preclinical and clinical studies showed that, when diffusion time t ≥ 200 ms, D(t) did not have a noticeable change while K(t) decreased monotonically with increasing diffusion time in tumors and t ≥ 100 ms for the cortical ribbon of the mouse brain. The estimated τ
conclusionThe results of this proof-of-concept study substantiate the feasibility of using tDKI to measure cellular-interstitial water exchange time without using an exogenous contrast agent.
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