ArticleTranslational stroke research2022
White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration.
Article in Translational stroke research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- The role of glymphatic dysfunction in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.International journal of stroke : official journal of the International Stroke Society · 2026Review
- Prognostic value of perivascular spaces, diffusion tensor imaging-derived indices, and choroid plexus in idiopathic normal pressure hydrocephalus.Neurosurgical review · 2025Article
- Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study.Fluids and barriers of the CNS · 2025Article
- Oxygen extraction fraction in small vessel disease: relationship to disease burden and progression.Brain : a journal of neurology · 2025Article
- Decreased Visibility of Deep Medullary Vein Associated with Cerebral Small Vessel Disease Burden through Increased Interstitial Fluid in White Matter.AJNR. American journal of neuroradiology · 2025Article
- Epigenetic age acceleration predicts subject-specific white matter degeneration in the human brain.Aging cell · 2025Article
- Association Between Single Nucleotide Polymorphisms in the Aquaporin-4 Gene and Longitudinal Changes in White Matter Free Water and Cognitive Function in Non-Demented Older Adults.Human brain mapping · 2025Article
- Free Water as a Marker of Early Small Vessel Disease in Healthy Aging.European journal of neurology · 2025Article
- Association of decreased visibility on deep medullary vein gray-matter volume mediated by increased extracellular fluid in the white matter of patients with cerebral small vessel disease.Quantitative imaging in medicine and surgery · 2025Article
- Free water as a potential mediator linking basal ganglia peri-vascular spaces to white matter hyperintensities in cerebral small vessel disease.Frontiers in neuroscience · 2025Article
- Deep medullary veins score is associated with atrophy in patients with cerebral small vessel disease.Frontiers in neurology · 2024Article
- Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures.Fluids and barriers of the CNS · 2023Article
- Superficial white matter microstructure affects processing speed in cerebral small vessel disease.Human brain mapping · 2022Article
- Free-water diffusion MRI detects structural alterations surrounding white matter hyperintensities in the early stage of cerebral small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- MRI free water as a biomarker for cognitive performance: Validation in the MarkVCID consortium.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging.Fluids and barriers of the CNS · 2021Article
- The Influence of Demographics and Vascular Risk Factors on Glymphatic Function Measured by Diffusion Along Perivascular Space.Frontiers in aging neuroscience · 2021Article
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the association between white matter free water (FW) and common imaging markers of cerebral small vessel diseases (CSVD) in two groups of subjects with different clinical status. One hundred and forty-four community subjects (mean age 60.5) and 84 CSVD subjects (mean age 61.2) were retrospectively included in the present study. All subjects received multi-modal magnetic resonance imaging and clinical assessments. The association between white matter FW and common CSVD imaging markers, including white matter hyperintensities (WMH), dilated perivascular space (PVS), lacunes, and microbleeds, were assessed using simple and multiple regression analysis. The association between FW and cognitive scores were also investigated. White matter FW was positively associated with WMH volume (β = 0.270, p = 0.001), PVS volume (β = 0.290, p < 0.001), number of microbleeds (β = 0.148, p = 0.043), and age (β = 0.170, p = 0.036) in the community cohort. In the CSVD cohort, FW was positively associated with WMH volume (β = 0.648, p < 0.001), PVS score (β = 0.224, p < 0.001), number of lacunes (β = 0.140, p = 0.046), and sex (β = 0.125, p = 0.036). The associations between FW and cognitive scores were stronger than conventional CSVD markers in both datasets. White matter FW is a potential composite marker that can sensitively detect cerebral small vessel degeneration and also reflect cognitive impairments.
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