Evidence map›Paper›PMID 33634365›Full record

ArticleBiological trace element research2022

Molecular Mechanism of Aluminum-Induced Oxidative Damage and Apoptosis in Rat Cardiomyocytes.

LiuFang Zhou, Mingjie He, XiaoLan Li, Erbing Lin, YingChuan Wang, Hua Wei, Xi Wei

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Testicular Toxicity in Rats Exposed to AlClBiological trace element research · 2024
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

LiuFang Zhou *Department of Cardiovascular Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Zhongshan No 2 Road, Baise, 18, China.
Mingjie He *Department of Endocrinology, Affiliated Hospital of Youjiang Medical University for Nationalities, Zhongshan No 2 Road, Baise, 18, China.
XiaoLan LiDepartment of Rehabilitation Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Zhongshan No 2 Road, Baise, 18, China.
Erbing LinDepartment of General Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Chengxiang Road, Baise, 98, China.
YingChuan WangDepartment of General Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Chengxiang Road, Baise, 98, China.
Hua WeiDepartment of General Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Chengxiang Road, Baise, 98, China.
Xi WeiDepartment of Health Supervision Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Zhongshan No 2 Road, Baise, 18, China. 191798113@qq.com.ORCID http://orcid.org/0000-0002-7623-8862
Affiliated Hospital of Youjiang Medical University for Nationalities · CN

Funding

Guangxi Science Natural Foundation for Young Scientists 2019JJB140036Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi (CN) 2019ky0556The First Batch of High-level Talent Scientifc Research Projects of the Afliated Hospital of Youjiang Medical University for Nationalities in 2019 R20196314
6 · The paper itself

Abstract

Aluminum exposure can mediate either acute toxicity or chronic toxicity. Aluminum exerts toxic effects on the cardiovascular system, but there are few studies on its related mechanisms. In this study, we investigated the molecular mechanism of aluminum-induced oxidative damage and apoptosis in rat cardiomyocytes. Thirty-two male Wistar rats were randomly divided into four groups, including the control group (GC), low-dose group of aluminum exposure (GL), medium-dose group (GM), and high-dose group (GH), with eight rats in each group. The GL, GM, and GH groups were given 5, 10, and 20 mg/(kg·d) of AlCl

Indexed as

AluminumMyocytes, CardiacAnimalsApoptosisMaleOxidative StressRatsRats, WistarAluminumAluminum exposureApoptosisCardiomyocyteOxidative damage

Identifiers

PMID33634365
OpenAlexW3132020753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.