Evidence map›Paper›PMID 33634267›Full record

ArticleCritical care explorations2021

Intranasal Orexin After Cardiac Arrest Leads to Increased Electroencephalographic Gamma Activity and Enhanced Neurologic Recovery in Rats.

David L Sherman, Autumn Williams, Sahithi Gd, Hiren R Modi, Qihong Wang, Nitish V Thakor, Romergryko G Geocadin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

David L ShermanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
Autumn WilliamsDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
Sahithi GdDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
Hiren R ModiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
Qihong WangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
Nitish V ThakorDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
Romergryko G GeocadinDepartments of Neurology, Anesthesiology-Critical Care Medicine, and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesProlonged cardiac arrest is known to cause global ischemic brain injury and functional impairment. Upon resuscitation, electroencephalographic recordings of brain activity begin to resume and can potentially be used to monitor neurologic recovery. We have previously shown that intrathecal orexin shows promise as a restorative drug and arousal agent in rodents. Our goal is to determine the electrophysiology effects of orexin in a rodent model of asphyxial cardiac arrest, focusing on the electroencephalographic activity in the gamma and super-gamma bands (indicative of return of higher brain function).

designExperimental animal study.

settingUniversity-based animal research laboratory. SUBJECTS: Adult male Wistar rats.

interventionsIn an established model of asphyxial cardiac arrest ( MEASUREMENTS AND MAIN

resultsCompared with the control cohort, the high-dose orexin cohort showed significantly better Neuro-Deficit Score 4 hours after return of spontaneous circulation (55.17 vs 47.58;

conclusionsOur findings support early and continuous monitoring of electroencephalography-based gamma activity as a marker of better functional recovery after intranasal administration of orexin as measured by Neuro-Deficit Score in an established animal model of asphyxial cardiac arrest.

Indexed as

asphyxiabrain injurycardiac arrestneurologic dysfunctionoutcome prediction

Identifiers

PMID33634267
PMCPMC7901796
OpenAlexW3132178768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.