Evidence map›Paper›PMID 33634255›Full record

ArticleCardiovascular endocrinology & metabolism2021

Association of serum leptin with angiographically proven cardiovascular disease and with components of the metabolic syndrome: a cross-sectional study in East Azerbaijan.

Nafiseh Khanbabaei, Hossein Mozafar Saadati, Shahnam Valizadeh Shahbazloo, Reyhaneh Hoseinpoor, Seyed Hossein Naderi, Roya Taghvamanesh, Sakhavat Abolhasani

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular endocrinology & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nafiseh KhanbabaeiDepartment of Clinical Biochemistry - Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences.
Hossein Mozafar SaadatiDepartment of Epidemiology, School of Public Health and Safety, Tehran.
Shahnam Valizadeh ShahbazlooDepartment of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz.
Reyhaneh HoseinpoorDepartment of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Hossein NaderiDepartment of Clinical Biochemistry - Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences.
Roya TaghvamaneshDepartment of Clinical Biochemistry - Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences.
Sakhavat AbolhasaniDepartment of Clinical Biochemistry - Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences.
Shahid Beheshti University of Medical Sciences · IRFaculty of Public Health · GBTabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRole of leptin is well documented in cardiometabolic diseases. The objective of this study was to investigate if the serum levels of leptin associates with the serum levels of markers related to cardiac and metabolic disorders in adults. MATERIALS AND

methodsOne hundred eighty subjects [120 cardiovascular disease (CVD) and 60 healthy controls] were enrolled in the study, to determine the association of the serum leptin (in quartiles) and cardiometabolic diseases [metabolic syndrome (MetS) and CVD] adjusted for other biological and physical examination. MetS was according to the WHO Clinical Criteria for MetS definition and CVD by angiography outcomes. The serum levels of leptin and OX-LDL were measured by ELISA.

resultsLeptin levels were significantly higher in patients with MetS and those with positive angiography compared with controls. After controlling for potential confounders, a significant association of the leptin levels with cardiometabolic diseases was proven, albeit there was a higher rate of significance between CVD and leptin in comparison with MetS. Additionally, receiver operating characteristic analysis revealed that the serum levels of leptin were a valuable biomarker of the cardiometabolic diseases.

conclusionOur findings demonstrate that serum leptin levels are associated with components of the MetS and with CVD. Serum leptin may be a useful biomarker for CVD.

Indexed as

biomarkercardiovascular diseaseleptinmetabolic syndromepopulation in East Azerbaijan

Identifiers

PMID33634255
PMCPMC7901824
OpenAlexW3049585113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.