ArticleCardiovascular endocrinology & metabolism2021
Androgen receptor-reduced sensitivity is associated with increased mortality and poorer glycaemia in men with type 2 diabetes mellitus: a prospective cohort study.
Article in Cardiovascular endocrinology & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Review
- Androgen receptor gene polymorphism and biological age markers in men.Scientific reports · 2025Article
- Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches.Endocrinology, diabetes & metabolism · 2025Review
- Systems Pharmacology-based Drug Discovery and Active Mechanism ofCurrent pharmaceutical design · 2025Article
- Molecular variants of multiple genes were revealed by whole-exome sequencing in PCOS patients with diabetes.Frontiers in genetics · 2025Article
- Adult Male Hypogonadism: A Laboratory Medicine Perspective on Its Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Review
- The British Society for Sexual Medicine Guidelines on Male Adult Testosterone Deficiency, with Statements for Practice.The world journal of men's health · 2023Review
- The AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia.International journal of biological sciences · 2023Article
- Androgen receptor polymorphism, testosterone levels, and prognosis in patients with acute myocardial infarction.European heart journal open · 2021Article
- Analysis of Sex Hormones, Insulin Dosage, and Risk Factors Associated With Male Diabetic Patients.American journal of men's healthArticle
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHypogonadism is associated with poorer glycaemic outcomes/increased all-cause and cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon-1 of the androgen receptor (AR) gene is associated with increased AR resistance/insulin resistance.
methodsWe determined in a long-term 14-year follow-up cohort of 423 T2DM Caucasian men, the association between baseline androgen status/CAG repeat number (by PCR then Sequenom sequencing) and metabolic/cardiovascular outcomes.
results
conclusionA higher number of CAG repeats at the AR gene associates with higher future HbA1c. There was a 'u' shaped relation between CAG repeat number and mortality rate. Determination of CAG repeat number may become part of assessment of androgen status/its consequences for men with T2DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.