Evidence map›Paper›PMID 33634122›Full record

ArticleFrontiers in cell and developmental biology2021

A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development.

Brian P Johnson, Ross A Vitek, Molly M Morgan, Dustin M Fink, Tyler G Beames, Peter G Geiger, David J Beebe, Robert J Lipinski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. A cell-based Sonic Hedgehog signaling transduction system to identify additive and synergistic chemical interactions.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  2. Article
  3. Article
  4. From mesenchymal niches to engineeredMaterials today. Bio · 2022
    Article
  5. Boosting the Clinical Translation of Organ-on-a-Chip Technology.Bioengineering (Basel, Switzerland) · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Brian P JohnsonDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, United States.
Ross A VitekDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, United States.
Molly M MorganDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, United States.
Dustin M FinkDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, United States.
Tyler G BeamesMolecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, United States.
Peter G GeigerDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, United States.
David J BeebeDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, United States.
Robert J LipinskiMolecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, United States.
University of Wisconsin–Madison · USMichigan State University · US

Funding

Developmental toxicity of pesticide synergist/Hedgehog inhibitor PBOR01ES026819 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI LIPINSKI, ROBERT · 2018 to 2022
$1.8M
Elucidating AHR signaling interplay in orofacial clefting and endocrine disruption using microplate microfluidicsR00ES028744 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHNSON, BRIAN P. · 2020 to 2022
$745k
Elucidating AHR signaling interplay in orofacial clefting and endocrine disruption using microplate microfluidicsK99ES028744 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, BRIAN P. · 2018 to 2019
$200k
NIEHS NIH HHS K99 ES028744NIEHS NIH HHS R00 ES028744NIEHS NIH HHS R01 ES026819
6 · The paper itself

Abstract

Paracrine signaling in the tissue microenvironment is a central mediator of morphogenesis, and modeling this dynamic intercellular activity

Indexed as

3D extracellular matrixchemical screeningcleft lip and palateembryonic morphogenesisepithelial mesenchymal cross-talkgene environment interactionparacrine signalingsignaling gradient

Identifiers

PMID33634122
PMCPMC7900501
OpenAlexW3128372566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.