Evidence map›Paper›PMID 33634081›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Elizabeth M Boazak, Rebecca King, Jiaxing Wang, Cassandra M Chu, Aaron M Toporek, Joseph M Sherwood, Darryl R Overby, Eldon E Geisert, C Ross Ethier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Elizabeth M BoazakWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, United States.
Rebecca KingDepartment of Ophthalmology, Emory University, Atlanta, GA, United States.
Jiaxing WangDepartment of Ophthalmology, Emory University, Atlanta, GA, United States.
Cassandra M ChuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, United States.
Aaron M ToporekWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, United States.
Joseph M SherwoodDepartment of Bioengineering, Imperial College London, London, United Kingdom.
Darryl R OverbyDepartment of Bioengineering, Imperial College London, London, United Kingdom.
Eldon E GeisertDepartment of Ophthalmology, Emory University, Atlanta, GA, United States.
C Ross EthierWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, United States.
Emory University · USGeorgia Institute of Technology · USImperial College London · GBThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI NICKERSON, JOHN M · 1986 to 2025
$15.3M
Targeting Scleral Stiffness as a Novel Therapeutic Approach in GlaucomaR01EY025286 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ETHIER, C ROSS · 2015 to 2019
$2.5M
NEI NIH HHS P30 EY006360NEI NIH HHS R01 EY025286
6 · The paper itself

Abstract

The biomechanical properties of the cornea and sclera are important in the onset and progression of multiple ocular pathologies and vary substantially between individuals, yet the source of this variation remains unknown. Here we identify genes putatively regulating corneoscleral biomechanical tissue properties by conducting high-fidelity ocular compliance measurements across the BXD recombinant inbred mouse set and performing quantitative trait analysis. We find seven cis-eQTLs and non-synonymous SNPs associating with ocular compliance, and show by RT-qPCR and immunolabeling that only two of the candidate genes,

Indexed as

corneal stiffnessglaucomamechanical propertiesmyopiaocular compliancescleral stiffnessSmarce1Tensin 4

Identifiers

PMID33634081
PMCPMC7902041
OpenAlexW3128665678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.