Evidence map›Paper›PMID 33634080›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Patient-Specific Computational Analysis of Hemodynamics and Wall Mechanics and Their Interactions in Pulmonary Arterial Hypertension.

Byron A Zambrano, Nathan McLean, Xiaodan Zhao, Ju-Le Tan, Liang Zhong, C Alberto Figueroa, Lik Chuan Lee, Seungik Baek

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Advancements and emerging trends in photodynamic therapy: innovations in cancer treatment and beyond.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Review
  5. Translation of Animal Study to Human: In Silico Based Development of Implantable Pulmonary Artery Pressure Sensor.International journal for numerical methods in biomedical engineering · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Byron A ZambranoJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, United States.
Nathan McLeanDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI, United States.
Xiaodan ZhaoNational Heart Centre Singapore, Singapore, Singapore.
Ju-Le TanNational Heart Centre Singapore, Singapore, Singapore.
Liang ZhongNational Heart Centre Singapore, Singapore, Singapore.
C Alberto FigueroaDepartments of Biomedical Engineering and Surgery, University of Michigan, Ann Arbor, MI, United States.
Lik Chuan LeeDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI, United States.
Seungik BaekDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI, United States.
Michigan State University · USNational Heart Centre Singapore · SGUniversity of Michigan–Ann Arbor · USWalker (United States) · US

Funding

Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary HypertensionU01HL135842 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAEK, SEUNGIK, DORFMAN, ADAM LEE · 2017 to 2020
$2.3M
NHLBI NIH HHS U01 HL135842
6 · The paper itself

Abstract

Vascular wall stiffness and hemodynamic parameters are potential biomechanical markers for detecting pulmonary arterial hypertension (PAH). Previous computational analyses, however, have not considered the interaction between blood flow and wall deformation. Here, we applied an established computational framework that utilizes patient-specific measurements of hemodynamics and wall deformation to analyze the coupled fluid-vessel wall interaction in the proximal pulmonary arteries (PA) of six PAH patients and five control subjects. Specifically, we quantified the linearized stiffness (

Indexed as

biomechanics metricsfluid structure interactionhemodynamicspulmonary arterial hypertensionpulmonary stiffness

Identifiers

PMID33634080
PMCPMC7901991
OpenAlexW3128855322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.