Evidence map›Paper›PMID 33633992›Full record

ArticleGland surgery2021

The effect of surgical approach on the outcomes and prognosis of high-risk histologic endometrioid carcinomas.

Zhihong Han, Zhong Zheng, Kai Tao, Yanping Yu, Jinping Wu, Xiaofei Tian

Abstract read
In one paragraph

Article in Gland surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Zhihong HanDepartment of Gynecologic Oncology, Shaanxi Provincial Tumor Hospital, Xi'an, China.
Zhong ZhengDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Kai TaoDepartment of Gynecologic Oncology, Shaanxi Provincial Tumor Hospital, Xi'an, China.
Yanping YuDepartment of Gynecologic Oncology, Shaanxi Provincial Tumor Hospital, Xi'an, China.
Jinping WuDepartment of Gynecology and Obstetrics, 521 Hospital of Norinco Group Xi'an, Xi'an, China.
Xiaofei TianDepartment of Gynecologic Oncology, Shaanxi Provincial Tumor Hospital, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-risk histologic endometrioid carcinomas include poorly differentiated endometrial carcinoma (PDEC), uterine clear cell carcinoma (UCCC), uterine carcinosarcoma (UCS), and uterine papillary serous carcinomas (UPCS). The purpose of this study was to investigate and compare the effect of open surgery and minimally invasive surgery on the prognosis of patients with high-risk endometrial cancer tissue types.

methodsA retrospective analysis was conducted to investigate 57 UCS or UPCS, 53 UCCC, and 110 PDEC patients receiving initial treatment at the Department of Gynecology in Shaanxi Provincial Tumor hospital and the Affiliated Hospital of Medical College of Xi'an Jiaotong University between February 2010 and January 2015. Prognostic factors were determined using univariate/multivariate analysis, and survival rates were assessed using the Kaplan-Meier method. The Cox regression model was adopted to assess the independent prognostic factors.

resultsTwo hundred and twenty patients who met the criteria were included in this study. At the end of follow-up period, 94 patients were still alive. Univariate analysis found that the survival time of the patients was related to staging, adjuvant therapy, and surgical approach. Multivariate analysis revealed that surgical approach, staging, pathology, and adjuvant therapy were independent prognostic factors.

conclusionsMinimally invasive surgery has a shorter survival time compared to open surgery in women with PDEC, UCCC, UCS, and UPCS. Multivariate analysis confirmed that staging, pathological type, surgical approach, and postoperative adjuvant therapy are independent risk factors for prognosis and affect the survival of women with PDEC, UCCC, UCS, and UPCS.

Indexed as

High-risk histologic endometrioid carcinomaslaparoscopic surgerylaparotomyoverall survival

Identifiers

PMID33633992
PMCPMC7882312

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